Structural changes in the hippocampus and amygdala at first episode of psychosis

David R. Watson, Feng Bai, Suzanne L. Barrett, Aidan Turkington, Teresa M. Rushe, Ciaran C. Mulholland, Stephen J. Cooper

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Hippocampus and amygdala changes have been implicated in the pathophysiology and symptomatology of both schizophrenia (SCZ) and bipolar disorder (BD). However relationships between illness course, neuropathological changes and variations in symptomatology remain unclear. This investigation examined the associations between hippocampus and amygdala volumes and symptom dimensions in schizophrenia and bipolar disorder patients after their first episode of psychosis. Symptom severity was associated with decreases in hippocampus/amygdala complex volume across groups. In keeping with previous work bilateral hippocampus and amygdala volume reductions were also identified in the SCZ patients while in BD patients only evidence of amygdala inflation reached significance. The study concludes that there appear to be important relationships between volume changes in the hippocampus and amygdala and dimensions and severity of symptomatology in psychosis. Structural alterations are apparent in both SCZ and BD after first episode of psychosis but present differently in each illness and are more severe in SCZ.

Original languageEnglish
Pages (from-to)49-60
Number of pages12
JournalBrain imaging and behavior
Volume6
Issue number1
DOIs
Publication statusPublished - Mar 2012

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience
  • Behavioral Neuroscience
  • Radiology Nuclear Medicine and imaging

Fingerprint

Dive into the research topics of 'Structural changes in the hippocampus and amygdala at first episode of psychosis'. Together they form a unique fingerprint.

Cite this