Structural mimics for the active site of [NiFe] hydrogenase

Andrew Marr, D.J.E. Spencer, M. Schroder

Research output: Contribution to journalArticle

142 Citations (Scopus)


Hydrogenases are enzymes that catalyse the reversible two-electron oxidation of H-2. The [NiFe] hydrogenases have been characterised spectroscopically and by single crystal X-ray diffraction, and show an active site incorporating a heterobinuclear [NiFe] centre bridged by two cysteine S-donors. Low molecular weight synthetic complex models, which structurally mimic the dithiolate-bridged [NiFe] centre, serve as important probes of structure and chemistry at the active site and are the subject of this review. (C) 2001 Elsevier Science B.V. All rights reserved.
Original languageEnglish
Pages (from-to)1055-1074
Number of pages20
JournalCoordination Chemistry Reviews
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

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