Structure-based design of selective high-affinity telomeric quadruplex-binding ligands.

C.M. Lombardo, I.S. Martinez, Shozeb Haider, V. Gabelica, E. De Pauw, J.E. Moses, S. Neidle

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


A library of triazole-based telomeric quadruplex-selective ligands has been developed that mimic an established family of tri-substituted acridine-based ligands, using crystal structure data as a starting-point for computer-based design. Binding affinities, estimated by electrospray mass spectrometry, are in accord with the design concept.
Original languageEnglish
Pages (from-to)9116-9118
Number of pages3
JournalChemical Communications
Issue number48
Publication statusPublished - 28 Dec 2010

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)


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