Structure-based design of selective high-affinity telomeric quadruplex-binding ligands.

C.M. Lombardo; I.S. Martinez; Shozeb Haider; V. Gabelica; E. De Pauw; J.E. Moses; S. Neidle

doi:10.1039/c0cc02917c

Structure-based design of selective high-affinity telomeric quadruplex-binding ligands.

C.M. Lombardo, I.S. Martinez, Shozeb Haider, V. Gabelica, E. De Pauw, J.E. Moses, S. Neidle

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

A library of triazole-based telomeric quadruplex-selective ligands has been developed that mimic an established family of tri-substituted acridine-based ligands, using crystal structure data as a starting-point for computer-based design. Binding affinities, estimated by electrospray mass spectrometry, are in accord with the design concept.

Original language	English
Pages (from-to)	9116-9118
Number of pages	3
Journal	Chemical Communications
Volume	46(48)
Issue number	48
DOIs	https://doi.org/10.1039/c0cc02917c
Publication status	Published - 28 Dec 2010

ASJC Scopus subject areas

Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Catalysis
General Chemistry

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10.1039/c0cc02917c

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title = "Structure-based design of selective high-affinity telomeric quadruplex-binding ligands.",

abstract = "A library of triazole-based telomeric quadruplex-selective ligands has been developed that mimic an established family of tri-substituted acridine-based ligands, using crystal structure data as a starting-point for computer-based design. Binding affinities, estimated by electrospray mass spectrometry, are in accord with the design concept.",

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AU - Martinez, I.S.

AU - Haider, Shozeb

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AU - De Pauw, E.

AU - Moses, J.E.

AU - Neidle, S.

PY - 2010/12/28

Y1 - 2010/12/28

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AB - A library of triazole-based telomeric quadruplex-selective ligands has been developed that mimic an established family of tri-substituted acridine-based ligands, using crystal structure data as a starting-point for computer-based design. Binding affinities, estimated by electrospray mass spectrometry, are in accord with the design concept.

U2 - 10.1039/c0cc02917c

DO - 10.1039/c0cc02917c

M3 - Article

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SN - 1359-7345

VL - 46(48)

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EP - 9118

JO - Chemical Communications

JF - Chemical Communications

IS - 48

ER -

Structure-based design of selective high-affinity telomeric quadruplex-binding ligands.

Abstract

ASJC Scopus subject areas

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