Structure-Based Mutational Analysis of eIF4E in Relation to sbm1 Resistance to Pea Seed-Borne Mosaic Virus in Pea

J.A. Ashby; C.E.M. Stevenson; Gavin Jarvis; D.M. Lawson; Aaron Maule

doi:10.1371/journal.pone.0015873

Structure-Based Mutational Analysis of eIF4E in Relation to sbm1 Resistance to Pea Seed-Borne Mosaic Virus in Pea

J.A. Ashby, C.E.M. Stevenson, Gavin Jarvis, D.M. Lawson, Aaron Maule

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Background: Pea encodes eukaryotic translation initiation factor eIF4E (eIF4E(S)), which supports the multiplication of Pea seed-borne mosaic virus (PSbMV). In common with hosts for other potyviruses, some pea lines contain a recessive allele (sbm1) encoding a mutant eIF4E (eIF4E(R)) that fails to interact functionally with the PSbMV avirulence protein, VPg, giving genetic resistance to infection.

Original language	English
Article number	e15873
Journal	PLoS ONE
Volume	6
Issue number	1
DOIs	https://doi.org/10.1371/journal.pone.0015873
Publication status	Published - 2011

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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abstract = "Background: Pea encodes eukaryotic translation initiation factor eIF4E (eIF4E(S)), which supports the multiplication of Pea seed-borne mosaic virus (PSbMV). In common with hosts for other potyviruses, some pea lines contain a recessive allele (sbm1) encoding a mutant eIF4E (eIF4E(R)) that fails to interact functionally with the PSbMV avirulence protein, VPg, giving genetic resistance to infection.",

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