Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity

G. Burton, T.W. Ku, T.J. Carr, T. Kiesow, R.T. Sarisky, J. Lin-Goerke, G.A. Hofmann, M.J. Slater, David Haigh, D. Dhanak, V.K. Johnson, N.R. Parry, P. Thommes

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

The SAR development is described for a series of N-acyl pyrrolidine inhibitors of the Hepatitis C virus RNA-dependent RNA polymerase, NS5B, from tractable Delta 21 enzyme inhibitors to an example with antiviral activity in a cellular assay (HCV replicon). (c) 2007 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)1930-1933
Number of pages4
JournalBioorganic & Medicinal Chemistry Letters
Volume17
Issue number7
DOIs
Publication statusPublished - 01 Apr 2007

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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