Studies on hemopoietic chimerism following allogeneic bone marrow transplantation in the molecular biology era

G Socie, M Lawler, E Gluckman, S R McCann, O Brison, Mark Lawler

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)

Abstract

Donor hematopoiesis or donor chimerism in the host following allogeneic bone marrow transplantation (BMT) has appeared crucial to the engraftment process. However, as molecular techniques exploiting neutral variation in human genetic material have been used in the study of chimerism, the detection of residual host cells or mixed hemopoietic chimerism has indicated that donor chimerism is not obligatory following BMT. This review focuses on the detection and significance of mixed chimerism (MC) in patients transplanted for both malignant and non-malignant hemopoietic disease and attempts to tease out the contribution of MC to engraftment, leukemia relapse, graft rejection and long-term disease-free survival.

Original languageEnglish
Pages (from-to)497-504
Number of pages8
JournalLeukemia research
Volume19
Issue number8
Publication statusPublished - Aug 1995

Keywords

  • Anemia, Aplastic
  • Bone Marrow Transplantation
  • Chimera
  • Graft vs Host Disease
  • Hematopoiesis
  • Humans
  • Leukemia
  • Neoplasm, Residual
  • Polymerase Chain Reaction
  • Polymorphism, Genetic
  • beta-Thalassemia

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