Studies on tridecaptin B(1), a lipopeptide with activity against multidrug resistant Gram-negative bacteria

Stephen A Cochrane, Christopher T Lohans, Marco J van Belkum, Manon A Bels, John C Vederas

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Previously other groups had reported that Paenibacillus polymyxa NRRL B-30507 produces SRCAM 37, a type IIA bacteriocin with antimicrobial activity against Campylobacter jejuni. Genome sequencing and isolation of antimicrobial compounds from this P. polymyxa strain show that the antimicrobial activity is due to polymyxins and tridecaptin B1. The complete structural assignment, synthesis, and antimicrobial profile of tridecaptin B1 is reported, as well as the putative gene cluster responsible for its biosynthesis. This peptide displays strong activity against multidrug resistant Gram-negative bacteria, a finding that is timely to the current problem of antibiotic resistance.

Original languageEnglish
Pages (from-to)6073-6081
JournalOrganic & biomolecular chemistry
Volume13
Issue number21
Early online date11 May 2015
DOIs
Publication statusPublished - 07 Jun 2015

Keywords

  • Amino Acid Sequence
  • Anti-Bacterial Agents
  • Gram-Negative Bacteria
  • Gram-Negative Bacterial Infections
  • Humans
  • Molecular Sequence Data
  • Multigene Family
  • Paenibacillus
  • Peptides
  • Polymyxins
  • Journal Article
  • Research Support, Non-U.S. Gov't

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