Studies on tridecaptin B(1), a lipopeptide with activity against multidrug resistant Gram-negative bacteria

Stephen A Cochrane; Christopher T Lohans; Marco J van Belkum; Manon A Bels; John C Vederas

doi:10.1039/c5ob00780a

Studies on tridecaptin B(1), a lipopeptide with activity against multidrug resistant Gram-negative bacteria

Stephen A Cochrane, Christopher T Lohans, Marco J van Belkum, Manon A Bels, John C Vederas

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Previously other groups had reported that Paenibacillus polymyxa NRRL B-30507 produces SRCAM 37, a type IIA bacteriocin with antimicrobial activity against Campylobacter jejuni. Genome sequencing and isolation of antimicrobial compounds from this P. polymyxa strain show that the antimicrobial activity is due to polymyxins and tridecaptin B1. The complete structural assignment, synthesis, and antimicrobial profile of tridecaptin B1 is reported, as well as the putative gene cluster responsible for its biosynthesis. This peptide displays strong activity against multidrug resistant Gram-negative bacteria, a finding that is timely to the current problem of antibiotic resistance.

Original language	English
Pages (from-to)	6073-6081
Journal	Organic & biomolecular chemistry
Volume	13
Issue number	21
Early online date	11 May 2015
DOIs	https://doi.org/10.1039/c5ob00780a
Publication status	Published - 07 Jun 2015

Keywords

Amino Acid Sequence
Anti-Bacterial Agents
Gram-Negative Bacteria
Gram-Negative Bacterial Infections
Humans
Molecular Sequence Data
Multigene Family
Paenibacillus
Peptides
Polymyxins
Journal Article
Research Support, Non-U.S. Gov't

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abstract = "Previously other groups had reported that Paenibacillus polymyxa NRRL B-30507 produces SRCAM 37, a type IIA bacteriocin with antimicrobial activity against Campylobacter jejuni. Genome sequencing and isolation of antimicrobial compounds from this P. polymyxa strain show that the antimicrobial activity is due to polymyxins and tridecaptin B1. The complete structural assignment, synthesis, and antimicrobial profile of tridecaptin B1 is reported, as well as the putative gene cluster responsible for its biosynthesis. This peptide displays strong activity against multidrug resistant Gram-negative bacteria, a finding that is timely to the current problem of antibiotic resistance.",

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doi = "10.1039/c5ob00780a",

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T1 - Studies on tridecaptin B(1), a lipopeptide with activity against multidrug resistant Gram-negative bacteria

AU - Cochrane, Stephen A

AU - Lohans, Christopher T

AU - van Belkum, Marco J

AU - Bels, Manon A

AU - Vederas, John C

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AB - Previously other groups had reported that Paenibacillus polymyxa NRRL B-30507 produces SRCAM 37, a type IIA bacteriocin with antimicrobial activity against Campylobacter jejuni. Genome sequencing and isolation of antimicrobial compounds from this P. polymyxa strain show that the antimicrobial activity is due to polymyxins and tridecaptin B1. The complete structural assignment, synthesis, and antimicrobial profile of tridecaptin B1 is reported, as well as the putative gene cluster responsible for its biosynthesis. This peptide displays strong activity against multidrug resistant Gram-negative bacteria, a finding that is timely to the current problem of antibiotic resistance.

KW - Amino Acid Sequence

KW - Anti-Bacterial Agents

KW - Gram-Negative Bacteria

KW - Gram-Negative Bacterial Infections

KW - Humans

KW - Molecular Sequence Data

KW - Multigene Family

KW - Paenibacillus

KW - Peptides

KW - Polymyxins

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

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DO - 10.1039/c5ob00780a

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JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

SN - 1477-0520

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ER -

Studies on tridecaptin B(1), a lipopeptide with activity against multidrug resistant Gram-negative bacteria

Abstract

Keywords

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