Study of the production yields of 18F, 11C, 13N and 15O positron emitters from plasma-laser proton sources at ELI-Beamlines for labeling of PET radiopharmaceuticals

Ernesto Amato; Antonio Italiano; Daniele Margarone; Benedetta Pagano; Sergio Baldari; Georg Korn

doi:10.1016/j.nima.2015.12.011

Study of the production yields of ¹⁸F, ¹¹C, ¹³N and ¹⁵O positron emitters from plasma-laser proton sources at ELI-Beamlines for labeling of PET radiopharmaceuticals

Ernesto Amato, Antonio Italiano^*, Daniele Margarone, Benedetta Pagano, Sergio Baldari, Georg Korn

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The development of novel compact PET radionuclide production systems is of great interest to promote the diffusion of PET diagnostics, especially in view of the continuous development of microfluidics labeling approaches. We studied the feasibility to produce clinically-relevant amounts of PET isotopes by means of laser-accelerated proton sources such that expected at the ELI-Beamlines facility. ¹⁸F, ¹¹C, ¹³N and ¹⁵O production yields were calculated through the TALYS software, by taking into account the broad proton spectra expected. With the hypothesized proton fluencies, clinically-relevant amounts of radionuclides can be obtained, suitable to prepare single doses of ¹⁸F-, ¹¹C- and ¹³N-labeled radiopharmaceuticals exploiting fast and efficient microfluidic labeling systems.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Volume	811
Early online date	17 Dec 2015
DOIs	https://doi.org/10.1016/j.nima.2015.12.011
Publication status	Published - 01 Mar 2016
Externally published	Yes

Keywords

Microfluidics
Plasma laser
Positron emission tomography
Proton acceleration

ASJC Scopus subject areas

Nuclear and High Energy Physics
Instrumentation

Access to Document

10.1016/j.nima.2015.12.011Licence: Unspecified

Cite this

Amato, E., Italiano, A., Margarone, D., Pagano, B., Baldari, S., & Korn, G. (2016). Study of the production yields of ¹⁸F, ¹¹C, ¹³N and ¹⁵O positron emitters from plasma-laser proton sources at ELI-Beamlines for labeling of PET radiopharmaceuticals. Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 811, 1-5. https://doi.org/10.1016/j.nima.2015.12.011

Amato, Ernesto ; Italiano, Antonio ; Margarone, Daniele et al. / Study of the production yields of ¹⁸F, ¹¹C, ¹³N and ¹⁵O positron emitters from plasma-laser proton sources at ELI-Beamlines for labeling of PET radiopharmaceuticals. In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2016 ; Vol. 811. pp. 1-5.

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title = "Study of the production yields of 18F, 11C, 13N and 15O positron emitters from plasma-laser proton sources at ELI-Beamlines for labeling of PET radiopharmaceuticals",

abstract = "The development of novel compact PET radionuclide production systems is of great interest to promote the diffusion of PET diagnostics, especially in view of the continuous development of microfluidics labeling approaches. We studied the feasibility to produce clinically-relevant amounts of PET isotopes by means of laser-accelerated proton sources such that expected at the ELI-Beamlines facility. 18F, 11C, 13N and 15O production yields were calculated through the TALYS software, by taking into account the broad proton spectra expected. With the hypothesized proton fluencies, clinically-relevant amounts of radionuclides can be obtained, suitable to prepare single doses of 18F-, 11C- and 13N-labeled radiopharmaceuticals exploiting fast and efficient microfluidic labeling systems.",

keywords = "Microfluidics, Plasma laser, Positron emission tomography, Proton acceleration",

author = "Ernesto Amato and Antonio Italiano and Daniele Margarone and Benedetta Pagano and Sergio Baldari and Georg Korn",

year = "2016",

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doi = "10.1016/j.nima.2015.12.011",

language = "English",

volume = "811",

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journal = "Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment",

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Amato, E, Italiano, A, Margarone, D, Pagano, B, Baldari, S & Korn, G 2016, 'Study of the production yields of ¹⁸F, ¹¹C, ¹³N and ¹⁵O positron emitters from plasma-laser proton sources at ELI-Beamlines for labeling of PET radiopharmaceuticals', Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol. 811, pp. 1-5. https://doi.org/10.1016/j.nima.2015.12.011

Study of the production yields of ¹⁸F, ¹¹C, ¹³N and ¹⁵O positron emitters from plasma-laser proton sources at ELI-Beamlines for labeling of PET radiopharmaceuticals. / Amato, Ernesto; Italiano, Antonio; Margarone, Daniele et al.
In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 811, 01.03.2016, p. 1-5.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Study of the production yields of 18F, 11C, 13N and 15O positron emitters from plasma-laser proton sources at ELI-Beamlines for labeling of PET radiopharmaceuticals

AU - Amato, Ernesto

AU - Italiano, Antonio

AU - Margarone, Daniele

AU - Pagano, Benedetta

AU - Baldari, Sergio

AU - Korn, Georg

PY - 2016/3/1

Y1 - 2016/3/1

N2 - The development of novel compact PET radionuclide production systems is of great interest to promote the diffusion of PET diagnostics, especially in view of the continuous development of microfluidics labeling approaches. We studied the feasibility to produce clinically-relevant amounts of PET isotopes by means of laser-accelerated proton sources such that expected at the ELI-Beamlines facility. 18F, 11C, 13N and 15O production yields were calculated through the TALYS software, by taking into account the broad proton spectra expected. With the hypothesized proton fluencies, clinically-relevant amounts of radionuclides can be obtained, suitable to prepare single doses of 18F-, 11C- and 13N-labeled radiopharmaceuticals exploiting fast and efficient microfluidic labeling systems.

AB - The development of novel compact PET radionuclide production systems is of great interest to promote the diffusion of PET diagnostics, especially in view of the continuous development of microfluidics labeling approaches. We studied the feasibility to produce clinically-relevant amounts of PET isotopes by means of laser-accelerated proton sources such that expected at the ELI-Beamlines facility. 18F, 11C, 13N and 15O production yields were calculated through the TALYS software, by taking into account the broad proton spectra expected. With the hypothesized proton fluencies, clinically-relevant amounts of radionuclides can be obtained, suitable to prepare single doses of 18F-, 11C- and 13N-labeled radiopharmaceuticals exploiting fast and efficient microfluidic labeling systems.

KW - Microfluidics

KW - Plasma laser

KW - Positron emission tomography

KW - Proton acceleration

U2 - 10.1016/j.nima.2015.12.011

DO - 10.1016/j.nima.2015.12.011

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JO - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

JF - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

ER -

Amato E, Italiano A, Margarone D, Pagano B, Baldari S, Korn G. Study of the production yields of ¹⁸F, ¹¹C, ¹³N and ¹⁵O positron emitters from plasma-laser proton sources at ELI-Beamlines for labeling of PET radiopharmaceuticals. Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2016 Mar 1;811:1-5. Epub 2015 Dec 17. doi: 10.1016/j.nima.2015.12.011