Study of the production yields of 18F, 11C, 13N and 15O positron emitters from plasma-laser proton sources at ELI-Beamlines for labeling of PET radiopharmaceuticals

Ernesto Amato, Antonio Italiano*, Daniele Margarone, Benedetta Pagano, Sergio Baldari, Georg Korn

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


The development of novel compact PET radionuclide production systems is of great interest to promote the diffusion of PET diagnostics, especially in view of the continuous development of microfluidics labeling approaches. We studied the feasibility to produce clinically-relevant amounts of PET isotopes by means of laser-accelerated proton sources such that expected at the ELI-Beamlines facility. 18F, 11C, 13N and 15O production yields were calculated through the TALYS software, by taking into account the broad proton spectra expected. With the hypothesized proton fluencies, clinically-relevant amounts of radionuclides can be obtained, suitable to prepare single doses of 18F-, 11C- and 13N-labeled radiopharmaceuticals exploiting fast and efficient microfluidic labeling systems.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalNuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Early online date17 Dec 2015
Publication statusPublished - 01 Mar 2016
Externally publishedYes


  • Microfluidics
  • Plasma laser
  • Positron emission tomography
  • Proton acceleration

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Instrumentation

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