Subgingival microbial diversity and respiratory decline: a cross‐sectional study

Lewis Winning; Gary Moran; Mary McClory; Ikhlas El Karim; Fionnuala T. Lundy; Christopher C. Patterson; Dermot Linden; Kathy M. Cullen; Frank Kee; Gerard J. Linden

doi:10.1111/jcpe.13819

Subgingival microbial diversity and respiratory decline: a cross‐sectional study

Lewis Winning^*, Gary Moran, Mary McClory, Ikhlas El Karim, Fionnuala T. Lundy, Christopher C. Patterson, Dermot Linden, Kathy M. Cullen, Frank Kee, Gerard J. Linden

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

47 Downloads (Pure)

Abstract

Aim
To investigate whether there is an association between subgingival microbial diversity and reduced respiratory function.

Materials and Methods
A group of dentate 58–72-year-old men in Northern Ireland had a comprehensive periodontal examination including subgingival plaque sampling. DNA was extracted from plaque samples and the V1–V3 regions of the 16S rRNA gene were analysed by high-throughput sequencing and a microbial diversity index (MDI) was derived. Spirometry measurements were made using a wedge bellows spirometer. The primary outcome variable of interest was the percentage of predicted forced expiratory volume in 1 s (% predicted FEV1). Analysis included multiple linear regression with adjustment for various confounders.

Results
Five-hundred and seven men were included in the analysis. The mean age was 63.6 years (SD = 3.1). Of these, 304 (60.0%) men had no or mild periodontitis, 105 (20.7%) had moderate periodontitis and 98 (19.3%) had severe periodontitis. Multiple linear regression analysis showed that a one unit increase in MDI was associated with a 0.71% loss (95% confidence interval: 0.06%–1.35%; p = .03) in % predicted FEV1 after adjustment for all confounders.

Conclusions
In this group of dentate men from Northern Ireland, subgingival microbial diversity was associated with reduced respiratory function.

Original language	English
Pages (from-to)	921-931
Number of pages	11
Journal	Journal of Clinical Periodontology
Volume	50
Issue number	7
Early online date	13 Apr 2023
DOIs	https://doi.org/10.1111/jcpe.13819
Publication status	Early online date - 13 Apr 2023

Keywords

ORIGINAL ARTICLE
ORIGINAL ARTICLES
chronic obstructive pulmonary disease
periodontitis
respiratory function
subgingival microbiome

Access to Document

10.1111/jcpe.13819Licence: CC BY

Subgingival microbial diversity and respiratory decline: a cross-sectional study
Copyright 2023 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 2.04 MBLicence: CC BY

Endodontic infections and cardiovascular disease risk: a prospective study of a possible link
McClory, M. (Author), El Karim, I. (Supervisor), Lundy, F. (Supervisor) & Linden, G. (Supervisor), Dec 2023
Student thesis: Doctoral Thesis › Doctor of Philosophy

Cite this

@article{3c3edc1d935248e8ae116675bb343d27,

title = "Subgingival microbial diversity and respiratory decline: a cross‐sectional study",

abstract = "AimTo investigate whether there is an association between subgingival microbial diversity and reduced respiratory function.Materials and MethodsA group of dentate 58–72-year-old men in Northern Ireland had a comprehensive periodontal examination including subgingival plaque sampling. DNA was extracted from plaque samples and the V1–V3 regions of the 16S rRNA gene were analysed by high-throughput sequencing and a microbial diversity index (MDI) was derived. Spirometry measurements were made using a wedge bellows spirometer. The primary outcome variable of interest was the percentage of predicted forced expiratory volume in 1 s (% predicted FEV1). Analysis included multiple linear regression with adjustment for various confounders.ResultsFive-hundred and seven men were included in the analysis. The mean age was 63.6 years (SD = 3.1). Of these, 304 (60.0%) men had no or mild periodontitis, 105 (20.7%) had moderate periodontitis and 98 (19.3%) had severe periodontitis. Multiple linear regression analysis showed that a one unit increase in MDI was associated with a 0.71% loss (95% confidence interval: 0.06%–1.35%; p = .03) in % predicted FEV1 after adjustment for all confounders.ConclusionsIn this group of dentate men from Northern Ireland, subgingival microbial diversity was associated with reduced respiratory function.",

keywords = "ORIGINAL ARTICLE, ORIGINAL ARTICLES, chronic obstructive pulmonary disease, periodontitis, respiratory function, subgingival microbiome",

author = "Lewis Winning and Gary Moran and Mary McClory and {El Karim}, Ikhlas and Lundy, {Fionnuala T.} and Patterson, {Christopher C.} and Dermot Linden and Cullen, {Kathy M.} and Frank Kee and Linden, {Gerard J.}",

year = "2023",

month = apr,

day = "13",

doi = "10.1111/jcpe.13819",

language = "English",

volume = "50",

pages = "921--931",

journal = "Journal of Clinical Periodontology",

issn = "0303-6979",

publisher = "Blackwell Munksgaard",

number = "7",

}

TY - JOUR

T1 - Subgingival microbial diversity and respiratory decline: a cross‐sectional study

AU - Winning, Lewis

AU - Moran, Gary

AU - McClory, Mary

AU - El Karim, Ikhlas

AU - Lundy, Fionnuala T.

AU - Patterson, Christopher C.

AU - Linden, Dermot

AU - Cullen, Kathy M.

AU - Kee, Frank

AU - Linden, Gerard J.

PY - 2023/4/13

Y1 - 2023/4/13

N2 - AimTo investigate whether there is an association between subgingival microbial diversity and reduced respiratory function.Materials and MethodsA group of dentate 58–72-year-old men in Northern Ireland had a comprehensive periodontal examination including subgingival plaque sampling. DNA was extracted from plaque samples and the V1–V3 regions of the 16S rRNA gene were analysed by high-throughput sequencing and a microbial diversity index (MDI) was derived. Spirometry measurements were made using a wedge bellows spirometer. The primary outcome variable of interest was the percentage of predicted forced expiratory volume in 1 s (% predicted FEV1). Analysis included multiple linear regression with adjustment for various confounders.ResultsFive-hundred and seven men were included in the analysis. The mean age was 63.6 years (SD = 3.1). Of these, 304 (60.0%) men had no or mild periodontitis, 105 (20.7%) had moderate periodontitis and 98 (19.3%) had severe periodontitis. Multiple linear regression analysis showed that a one unit increase in MDI was associated with a 0.71% loss (95% confidence interval: 0.06%–1.35%; p = .03) in % predicted FEV1 after adjustment for all confounders.ConclusionsIn this group of dentate men from Northern Ireland, subgingival microbial diversity was associated with reduced respiratory function.

AB - AimTo investigate whether there is an association between subgingival microbial diversity and reduced respiratory function.Materials and MethodsA group of dentate 58–72-year-old men in Northern Ireland had a comprehensive periodontal examination including subgingival plaque sampling. DNA was extracted from plaque samples and the V1–V3 regions of the 16S rRNA gene were analysed by high-throughput sequencing and a microbial diversity index (MDI) was derived. Spirometry measurements were made using a wedge bellows spirometer. The primary outcome variable of interest was the percentage of predicted forced expiratory volume in 1 s (% predicted FEV1). Analysis included multiple linear regression with adjustment for various confounders.ResultsFive-hundred and seven men were included in the analysis. The mean age was 63.6 years (SD = 3.1). Of these, 304 (60.0%) men had no or mild periodontitis, 105 (20.7%) had moderate periodontitis and 98 (19.3%) had severe periodontitis. Multiple linear regression analysis showed that a one unit increase in MDI was associated with a 0.71% loss (95% confidence interval: 0.06%–1.35%; p = .03) in % predicted FEV1 after adjustment for all confounders.ConclusionsIn this group of dentate men from Northern Ireland, subgingival microbial diversity was associated with reduced respiratory function.

KW - ORIGINAL ARTICLE

KW - ORIGINAL ARTICLES

KW - chronic obstructive pulmonary disease

KW - periodontitis

KW - respiratory function

KW - subgingival microbiome

U2 - 10.1111/jcpe.13819

DO - 10.1111/jcpe.13819

M3 - Article

SN - 0303-6979

VL - 50

SP - 921

EP - 931

JO - Journal of Clinical Periodontology

JF - Journal of Clinical Periodontology

IS - 7

ER -

Subgingival microbial diversity and respiratory decline: a cross‐sectional study

Abstract

Keywords

Access to Document

Fingerprint

Student theses

Endodontic infections and cardiovascular disease risk: a prospective study of a possible link

Cite this