SUBLINGUAL CAPTOPRIL - A PHARMACOKINETIC AND PHARMACODYNAMIC EVALUATION

T.A. Alfuraih, James McElnay, J.S. Elborn, R. Rusk, M.G. Scott, J. Mcmahon, D.P. Nicholls

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

In this study we compared the pharmacokinetics and pharmacodynamics of captopril after sublingual and peroral administration. Single 25 mg doses of captopril were administered sublingually and perorally on two different occasions in a randomised cross-over fashion to eight healthy volunteers aged 22-35 years. The kinetics of unchanged captopril, plasma renin activity (PRA), BP and heart rate were studied over three hours after both peroral and sublingual administration of captopril.
Original languageEnglish
Pages (from-to)393-398
Number of pages6
JournalEuropean Journal of Clinical Pharmacology
Volume40
Publication statusPublished - 1991

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