SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME

Luke A.J. O'Neill (Inventor), Rebecca Coll (Inventor), Matthew A Cooper (Inventor), Avril A B Robertson (Inventor), Kate Schroder (Inventor), Angus Murray Macleod (Inventor), David John Miller (Inventor)

Research output: Patent

Abstract

The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts, solvates and prodrugs thereof: Formula (I) wherein Q is selected from O, S and Se; J is S or Se; W1 and W2, when present, are independently selected from N and C; R1 and R2 are independently selected from the group consisting of hydrogen, C1-C12alkyl, C2-C12alkenyl, C2-C12alkynyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, cycloalkenyl, amino, amido, alkylthio, acyl, arylalkyl and acylamido, all of which may be optionally substituted; and wherein at least one of W1 and W2 is present and is a nitrogen atom and when R1 and R2 are cyclic then the respective W1 or W2 may form part of the ring structure. The present invention also relates to pharmaceutical compositions including such compounds, to methods of treatment using such compounds, in particular in relation to NLRP3 inflammasome mediated disorders, and to associated diagnostic uses.
Original languageEnglish
Patent numberPCT/EP2017/053498
Priority date16/02/2016
Filing date16/02/2017
Publication statusPublished - 24 Aug 2017

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Patents and inventions
Inflammasomes
Prodrugs
Hydrogen
Nitrogen
Salts
Atoms
Chemical analysis
Pharmaceutical Preparations

Cite this

O'Neill, L. A. J., Coll, R., Cooper, M. A., Robertson, A. A. B., Schroder, K., Macleod, A. M., & Miller, D. J. (2017). SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME. (Patent No. PCT/EP2017/053498).
O'Neill, Luke A.J. (Inventor) ; Coll, Rebecca (Inventor) ; Cooper, Matthew A (Inventor) ; Robertson, Avril A B (Inventor) ; Schroder, Kate (Inventor) ; Macleod, Angus Murray (Inventor) ; Miller, David John (Inventor). / SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME. Patent No.: PCT/EP2017/053498. Feb 16, 2017.
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title = "SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME",
abstract = "The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts, solvates and prodrugs thereof: Formula (I) wherein Q is selected from O, S and Se; J is S or Se; W1 and W2, when present, are independently selected from N and C; R1 and R2 are independently selected from the group consisting of hydrogen, C1-C12alkyl, C2-C12alkenyl, C2-C12alkynyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, cycloalkenyl, amino, amido, alkylthio, acyl, arylalkyl and acylamido, all of which may be optionally substituted; and wherein at least one of W1 and W2 is present and is a nitrogen atom and when R1 and R2 are cyclic then the respective W1 or W2 may form part of the ring structure. The present invention also relates to pharmaceutical compositions including such compounds, to methods of treatment using such compounds, in particular in relation to NLRP3 inflammasome mediated disorders, and to associated diagnostic uses.",
author = "O'Neill, {Luke A.J.} and Rebecca Coll and Cooper, {Matthew A} and Robertson, {Avril A B} and Kate Schroder and Macleod, {Angus Murray} and Miller, {David John}",
year = "2017",
month = "8",
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type = "Patent",
note = "PCT/EP2017/053498",

}

O'Neill, LAJ, Coll, R, Cooper, MA, Robertson, AAB, Schroder, K, Macleod, AM & Miller, DJ Feb. 16 2017, SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME, Patent No. PCT/EP2017/053498.

SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME. / O'Neill, Luke A.J. (Inventor); Coll, Rebecca (Inventor); Cooper, Matthew A (Inventor); Robertson, Avril A B (Inventor); Schroder, Kate (Inventor); Macleod, Angus Murray (Inventor); Miller, David John (Inventor).

Patent No.: PCT/EP2017/053498. Feb 16, 2017.

Research output: Patent

TY - PAT

T1 - SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME

AU - O'Neill, Luke A.J.

AU - Coll, Rebecca

AU - Cooper, Matthew A

AU - Robertson, Avril A B

AU - Schroder, Kate

AU - Macleod, Angus Murray

AU - Miller, David John

PY - 2017/8/24

Y1 - 2017/8/24

N2 - The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts, solvates and prodrugs thereof: Formula (I) wherein Q is selected from O, S and Se; J is S or Se; W1 and W2, when present, are independently selected from N and C; R1 and R2 are independently selected from the group consisting of hydrogen, C1-C12alkyl, C2-C12alkenyl, C2-C12alkynyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, cycloalkenyl, amino, amido, alkylthio, acyl, arylalkyl and acylamido, all of which may be optionally substituted; and wherein at least one of W1 and W2 is present and is a nitrogen atom and when R1 and R2 are cyclic then the respective W1 or W2 may form part of the ring structure. The present invention also relates to pharmaceutical compositions including such compounds, to methods of treatment using such compounds, in particular in relation to NLRP3 inflammasome mediated disorders, and to associated diagnostic uses.

AB - The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts, solvates and prodrugs thereof: Formula (I) wherein Q is selected from O, S and Se; J is S or Se; W1 and W2, when present, are independently selected from N and C; R1 and R2 are independently selected from the group consisting of hydrogen, C1-C12alkyl, C2-C12alkenyl, C2-C12alkynyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, cycloalkenyl, amino, amido, alkylthio, acyl, arylalkyl and acylamido, all of which may be optionally substituted; and wherein at least one of W1 and W2 is present and is a nitrogen atom and when R1 and R2 are cyclic then the respective W1 or W2 may form part of the ring structure. The present invention also relates to pharmaceutical compositions including such compounds, to methods of treatment using such compounds, in particular in relation to NLRP3 inflammasome mediated disorders, and to associated diagnostic uses.

M3 - Patent

M1 - PCT/EP2017/053498

Y2 - 2017/02/16

ER -

O'Neill LAJ, Coll R, Cooper MA, Robertson AAB, Schroder K, Macleod AM et al, inventors. SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME. PCT/EP2017/053498. 2017 Aug 24.