Sulfoxides of high enantiopurity from bacterial dioxygenase-catalysed oxidation

Christopher C R Allen, Derek R. Boyd*, Howard Dalton, Narain D. Sharma, Simon A. Haughey, R. Austin S. McMordie, Brian T. McMurray, Gary N. Sheldrake, Kenneth Sproule

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

63 Citations (Scopus)

Abstract

Selected strains of the bacterium Pseudomonas putida (previously shown to effect dioxygenase-catalysed asymmetric cis-dihydroxylation of alkenes) have been found to yield chiral sulfoxides from the corresponding sulfides with a strong preference for the (R)- or (S)-configurations but without evidence of sulfone formation; similar results obtained using an Escherichia coli clone (pKST11, containing the Tod C1 C2 B and A genes encoding toluene dioxygenase from P. putida NCIMB 11767) are again consistent with a stereoselective dioxygenase-catalysed sulfoxidation.

Original languageEnglish
Pages (from-to)119-120
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number2
DOIs
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Molecular Medicine

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