11Boron delivery agents for boron proton-capture enhanced proton therapy

Katalin Hideghéty, Szilvia Brunner*, Andrew Cheesman, Emilia Rita Szabó, Róbert Polanek, Daniele Margarone, Tünde Tőkés, Károly Mogyorósi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

The aim of this review was to define appropriate 11B delivery agents for boron proton-capture enhanced proton therapy (BPCEPT) taking into account the accumulated knowledge on boron compounds used for boron neutron capture therapy (BNCT). BPCEPT is a promising treatment approach which uses a high linear energy transfer (LET) dose component in conjunction with conventional proton therapy to increase the relative biological effectiveness of highly-selective charged particle therapy. Boron proton fusion reactions occur with highest cross section at certain proton energy level and thus can be tailored to the target volume with careful treatment planning that defines the 675 MeV proton distribution with high accuracy. Appropriate 11B compounds are required in order to achieve relevant high LET dose contribution from the boron proton-capture reaction. Previous scientific results and experiences with BNCT provide background knowledge and information regarding the optimization of boronated compound development, their characterization, measurement and imaging. However, there are substantial differences between BNCT and BPCEPT, which in turn places special unique chemical, physical and biological demands on 11B-carrier compounds for BPCEPT. In this review, we evaluate well-known and recently developed boron compounds for BPCEPT.

Original languageEnglish
Pages (from-to)2265-2276
Number of pages12
JournalAnticancer Research
Volume39
Issue number5
DOIs
Publication statusPublished - 01 May 2019
Externally publishedYes

Keywords

  • BNCT
  • Boron delivery agents
  • Boron-neutron capture therapy
  • Boron-proton capture enhanced proton therapy BPCEPT
  • Review

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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