Cytokines are important modulators of homeostatic processes such as development, haematopoiesis and host defence, A recently identified family of proteins, the supressors of cytokine signalling (SOCS) act as negative regulators of the key cytokine-activated signalling pathway, the Janus kinase/signal transducers and activators of transcription (JAK/STAT) cascade, In the current review, the discovery, structural features, regulation of expression, mechanisms of JAK/STAT inhibition and putative role in health and disease of the SOCS family are discussed.
|Number of pages||6|
|Journal||Journal of Nephrology|
|Publication status||Published - Jan 2000|
ASJC Scopus subject areas
Diamond, J., Doran, P., Brady, J., & McGinty, A. (2000). Suppressors of cytokine signalling (SOCS): putative modulators of cytokine bioactivity in health and disease. Journal of Nephrology, 13(1), 9-14.