Suppressors of cytokine signalling (SOCS): putative modulators of cytokine bioactivity in health and disease

James Diamond, Peter Doran, Jonathan Brady, Ann McGinty

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Cytokines are important modulators of homeostatic processes such as development, haematopoiesis and host defence, A recently identified family of proteins, the supressors of cytokine signalling (SOCS) act as negative regulators of the key cytokine-activated signalling pathway, the Janus kinase/signal transducers and activators of transcription (JAK/STAT) cascade, In the current review, the discovery, structural features, regulation of expression, mechanisms of JAK/STAT inhibition and putative role in health and disease of the SOCS family are discussed.
Original languageEnglish
Pages (from-to)9-14
Number of pages6
JournalJournal of Nephrology
Volume13
Issue number1
Publication statusPublished - Jan 2000

ASJC Scopus subject areas

  • Nephrology

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