This paper reports a surface modification of epoxy-based negative photoresist SU-8 for reducing its autofluorescence while enhancing its biofunctionality. By covalently depositing a thin layer of 20 nm Au nanoparticles (AuNPs) onto the SU-8 surface, we found that the AuNPs-coated SU-8 surface is much less fluorescent than the untreated SU-8. Moreover, DNA probes can easily be immobilized on the Au surface and are thermally stable over a wide range of temperature. These improvements will benefit bioanalytical applications such as DNA hybridization and solid-phase PCR (SP-PCR).
|Number of pages
|Published - 2011
|Fifteenth International Conference on Miniaturized Systems for Chemistry and Life Sciences (TAS 2011) - Seattle, United States
Duration: 02 Oct 2011 → 06 Oct 2011
|Fifteenth International Conference on Miniaturized Systems for Chemistry and Life Sciences (TAS 2011)
|02/10/2011 → 06/10/2011