Surface Modification of Photoresist SU-8 for Low Autofluorescence and Bioanalytical Applications

Cuong Cao; SW Birtwell; J Hogberg; A Wolff; H Morgan; DD Bang

Surface Modification of Photoresist SU-8 for Low Autofluorescence and Bioanalytical Applications

Cuong Cao, SW Birtwell, J Hogberg, A Wolff, H Morgan, DD Bang

School of Biological Sciences

Research output: Contribution to conference › Paper › peer-review

5 Citations (Scopus)

Abstract

This paper reports a surface modification of epoxy-based negative photoresist SU-8 for reducing its autofluorescence while enhancing its biofunctionality. By covalently depositing a thin layer of 20 nm Au nanoparticles (AuNPs) onto the SU-8 surface, we found that the AuNPs-coated SU-8 surface is much less fluorescent than the untreated SU-8. Moreover, DNA probes can easily be immobilized on the Au surface and are thermally stable over a wide range of temperature. These improvements will benefit bioanalytical applications such as DNA hybridization and solid-phase PCR (SP-PCR).

Original language	English
Pages	1161-1163
Number of pages	3
Publication status	Published - 2011
Event	Fifteenth International Conference on Miniaturized Systems for Chemistry and Life Sciences (TAS 2011) - Seattle, United States Duration: 02 Oct 2011 → 06 Oct 2011

Conference

Conference	Fifteenth International Conference on Miniaturized Systems for Chemistry and Life Sciences (TAS 2011)
Country/Territory	United States
City	Seattle
Period	02/10/2011 → 06/10/2011

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http://www.rsc.org/images/LOC/2011/PDFs/Papers/389_0159.pdf

Cite this

Cao, C., Birtwell, SW., Hogberg, J., Wolff, A., Morgan, H., & Bang, DD. (2011). Surface Modification of Photoresist SU-8 for Low Autofluorescence and Bioanalytical Applications. 1161-1163. Paper presented at Fifteenth International Conference on Miniaturized Systems for Chemistry and Life Sciences (TAS 2011), Seattle, United States. http://www.rsc.org/images/LOC/2011/PDFs/Papers/389_0159.pdf

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title = "Surface Modification of Photoresist SU-8 for Low Autofluorescence and Bioanalytical Applications",

abstract = "This paper reports a surface modification of epoxy-based negative photoresist SU-8 for reducing its autofluorescence while enhancing its biofunctionality. By covalently depositing a thin layer of 20 nm Au nanoparticles (AuNPs) onto the SU-8 surface, we found that the AuNPs-coated SU-8 surface is much less fluorescent than the untreated SU-8. Moreover, DNA probes can easily be immobilized on the Au surface and are thermally stable over a wide range of temperature. These improvements will benefit bioanalytical applications such as DNA hybridization and solid-phase PCR (SP-PCR). ",

author = "Cuong Cao and SW Birtwell and J Hogberg and A Wolff and H Morgan and DD Bang",

year = "2011",

language = "English",

pages = "1161--1163",

note = "Fifteenth International Conference on Miniaturized Systems for Chemistry and Life Sciences (TAS 2011) ; Conference date: 02-10-2011 Through 06-10-2011",

}

Cao, C, Birtwell, SW, Hogberg, J, Wolff, A, Morgan, H & Bang, DD 2011, 'Surface Modification of Photoresist SU-8 for Low Autofluorescence and Bioanalytical Applications', Paper presented at Fifteenth International Conference on Miniaturized Systems for Chemistry and Life Sciences (TAS 2011), Seattle, United States, 02/10/2011 - 06/10/2011 pp. 1161-1163. <http://www.rsc.org/images/LOC/2011/PDFs/Papers/389_0159.pdf>

Surface Modification of Photoresist SU-8 for Low Autofluorescence and Bioanalytical Applications. / Cao, Cuong; Birtwell, SW; Hogberg, J et al.
2011. 1161-1163 Paper presented at Fifteenth International Conference on Miniaturized Systems for Chemistry and Life Sciences (TAS 2011), Seattle, United States.

Research output: Contribution to conference › Paper › peer-review

TY - CONF

T1 - Surface Modification of Photoresist SU-8 for Low Autofluorescence and Bioanalytical Applications

AU - Cao, Cuong

AU - Birtwell, SW

AU - Hogberg, J

AU - Wolff, A

AU - Morgan, H

AU - Bang, DD

PY - 2011

Y1 - 2011

N2 - This paper reports a surface modification of epoxy-based negative photoresist SU-8 for reducing its autofluorescence while enhancing its biofunctionality. By covalently depositing a thin layer of 20 nm Au nanoparticles (AuNPs) onto the SU-8 surface, we found that the AuNPs-coated SU-8 surface is much less fluorescent than the untreated SU-8. Moreover, DNA probes can easily be immobilized on the Au surface and are thermally stable over a wide range of temperature. These improvements will benefit bioanalytical applications such as DNA hybridization and solid-phase PCR (SP-PCR).

AB - This paper reports a surface modification of epoxy-based negative photoresist SU-8 for reducing its autofluorescence while enhancing its biofunctionality. By covalently depositing a thin layer of 20 nm Au nanoparticles (AuNPs) onto the SU-8 surface, we found that the AuNPs-coated SU-8 surface is much less fluorescent than the untreated SU-8. Moreover, DNA probes can easily be immobilized on the Au surface and are thermally stable over a wide range of temperature. These improvements will benefit bioanalytical applications such as DNA hybridization and solid-phase PCR (SP-PCR).

M3 - Paper

SP - 1161

EP - 1163

T2 - Fifteenth International Conference on Miniaturized Systems for Chemistry and Life Sciences (TAS 2011)

Y2 - 2 October 2011 through 6 October 2011

ER -

Surface Modification of Photoresist SU-8 for Low Autofluorescence and Bioanalytical Applications

Abstract

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