Surgical optimisation and characterisation of a minimally invasive aortic banding procedure to induce cardiac hypertrophy in mice

Tamara P. Martin, Emma Robinson, Adam P. Harvey, Margaret A. MacDonald, David J. Grieve, Andrew Paul, Susan Currie

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Left ventricular pressure overload in response to aortic banding is an invaluable model for studying progression of cardiac hypertrophy and transition to heart failure. Traditional aortic banding has recently been superceded by minimally invasive transverse aortic banding (MTAB) which does not require ventilation so is less technically challenging. Although the MTAB procedure is superior, few laboratories have documented success and minimal information on the model is available. The aim of this study was to optimise conditions for MTAB and to characterise the development and progression of cardiac hypertrophy. Isofluorane proved the most suitable anaesthetic for MTAB surgery in mice and one week after surgery MTAB animals showed significant increases in systolic blood pressure (110±6 v's 78±3(mmHg), MTAB v's sham, n=7,p
Original languageEnglish
Pages (from-to)822-832
JournalExperimental Physiology
Volume97
Issue number7
Early online date31 May 2012
DOIs
Publication statusPublished - 11 Jul 2012

ASJC Scopus subject areas

  • Physiology

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