Survival of HIV-1 and HIV-2 perinatally infected children in The Gambia

Maarten F Schim van der Loeff, Andreas Hansmann, Akum Aveika Awasana, Martin O Ota, Diarmuid O'Donovan, Ramu Sarge-Njie, Koya Ariyoshi, Paul Milligan, Hilton Whittle

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

BACKGROUND: The risk of mother-to-child transmission (MTCT) of HIV-2 is much lower than that of HIV-1, but the long-term prognosis of perinatally infected HIV-2 children is unknown. We re-visited children who were part of a large MTCT study in The Gambia (conducted during 1993-1997), in order to compare the long-term survival of children perinatally infected with HIV-2 with that of seronegative and of HIV-1 infected children.

METHODS: Five to eight years' follow-up of a cohort of children born to HIV-negative, HIV-1 positive, and HIV-2 positive mothers.

RESULTS: Seven hundred and seventy-four children were followed up for a median of 6.6 years. Of 17 perinatally HIV-1 infected children, three were still alive on 1 July 2001, two had been lost to follow-up, and 12 had died. The median survival was 2.5 years. Of eight HIV-2 infected children five were still alive, none were lost to follow-up and three had died. The mortality hazards ratio of both HIV-1 [9.9; 95% confidence interval (CI), 5.2-19], and of HIV-2 infected children (3.9; CI, 1.2-12) was significantly increased compared with children of seronegative mothers. The mortality hazards ratio of HIV uninfected children of HIV-1 or HIV-2 infected mothers was not significantly increased compared to that of children of seronegative mothers (P = 0.17 and P = 0.5 respectively).

CONCLUSIONS: Children with perinatally acquired HIV-2 infection have a higher mortality than children of seronegative mothers. Guidelines for treatment of HIV-1 infected children should be used for treatment of HIV-2 infected children.

Original languageEnglish
Pages (from-to)2389-94
Number of pages6
JournalAIDS (London, England)
Volume17
Issue number16
DOIs
Publication statusPublished - 07 Nov 2003

Keywords

  • Developing Countries
  • Female
  • Follow-Up Studies
  • Gambia/epidemiology
  • HIV Infections/mortality
  • HIV-1
  • HIV-2
  • Humans
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical
  • Male
  • Pregnancy
  • Pregnancy Complications, Infectious
  • Prognosis
  • Survival Analysis

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