Abstract
BACKGROUND The incidence of oesophageal adenocarcinoma (OAC) has been reported to be increasing in many countries. Alongside this trend, an increase in incidence of early-onset OAC, defined as OAC in adults aged under 50 years, has been observed. It is unclear whether survival outcomes for early-onset OAC patients differ from older age groups. AIM To investigate survival outcomes in early-onset OAC patients.
METHODS Ovid Medline and Embase were searched from inception to January 2022 for relevant studies relating to early-onset OAC and survival outcomes. Results regarding the overall five-year survival and risk of death of younger and older patients with OAC were extracted and pooled using meta-analyses to produce pooled estimates and 95%CIs where possible.
RESULTS Eleven studies which compared survival of early-onset OAC, defined as age at diagnosis of < 50 years, with older patients were included. A narrative review of median and mean survival demonstrated conflicting results, with studies showing early-onset OAC patients having both better and worse outcomes compared to older age groups. A meta-analysis of five-year survival demonstrated similar outcomes across age groups, with 22%-25% of patients in the young, middle and older age groups alive after five years. A meta-analysis of four studies demonstrated that early-onset OAC patients did not have a significantly increased risk of death compared to middle-aged patients (hazard ratio 1.12, 95%CI: 0.85-1.47).
CONCLUSION Results suggest that early-onset OAC patients do not have a significantly different survival compared to older patients, but further population-based research, taking into account stage and treatment, is required.
Original language | English |
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Pages (from-to) | 4221-4231 |
Number of pages | 11 |
Journal | World Journal of Gastroenterology |
Volume | 30 |
Issue number | 38 |
DOIs | |
Publication status | Published - 14 Oct 2024 |
Bibliographical note
Publisher Copyright:©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Keywords
- Cancer epidemiology
- Early-onset cancer
- Early-onset oesophageal adenocarcinoma
- Meta-analysis
- Survival
- Systematic review
ASJC Scopus subject areas
- Gastroenterology