Susceptibility of VLDL to oxidation in patients on regular haemodialysis

Jane McEneny, C.M. Loughrey, P.T. McNamee, Elizabeth Trimble, Ian Young

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Oxidation of VLDL in vitro increases macrophage uptake and promotes foam cell formation, and the dyslipidaemia of chronic renal failure is characterised by an increase in VLDL. However, little information is available with regard to the susceptibility of VLDL to oxidation in patients at increased risk of atherosclerosis. We have therefore assessed the composition and susceptibility to oxidation of VLDL from haemodialysis patients anti control subjects. VLDL from haemodialysis patients contained increased lipid hydroperoxides (81.6 +/- 12.6 versus 16.1 +/- 3.4 nmol/mg protein, P
Original languageEnglish
Pages (from-to)215-220
Number of pages6
JournalAtherosclerosis
Volume129
Publication statusPublished - 1997

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