Sustainable access to 5‐amino‐oxazoles and thiazoles via calcium‐catalyzed elimination‐cyclization with isocyanides

Ashley J. Basson, Mark G. McLaughlin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)
11 Downloads (Pure)

Abstract

Herein, we report a sustainable, modular, rapid and high-yielding transformation to afford densely functionalized 5-aminooxazoles and thiazoles. The reaction is tolerant to a wide range of functional groups and is typically complete in under 30 min. Furthermore, the described transformation is inherently green in relation to the catalyst and solvent choice as well as producing environmentally benign alcoholic by-products
Original languageEnglish
Pages (from-to)1696-1699
JournalChemSusChem
Volume14
Issue number7
Early online date19 Feb 2021
DOIs
Publication statusPublished - 09 Apr 2021
Externally publishedYes

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