Sustained release of proteins from a modified vaginal ring device

Ryan J Morrow, A David Woolfson, Louise Donnelly, Rhonda Curran, Gavin Andrews, Dietmar Katinger, R Karl Malcolm

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)

Abstract

A new vaginal ring technology, the insert vaginal ring (InVR), is presented. The InVR overcomes the current shortfall of conventional vaginal rings (VRs) that are generally ineffectual for the delivery of hydrophilic and/or macromolecular actives, including peptides, proteins and antibodies, due to their poor permeation characteristics in the hydrophobic polymeric elastomers from which VRs are usually fabricated. Release of the model protein BSA from a variety of insert matrices for the InVR is demonstrated, including modified silicone rods, directly compressed tablets and lyophilised gels, which collectively provided controlled release profiles from several hours to beyond 4 weeks. Furthermore, the InVR was shown to deliver over 1 mg of the monoclonal antibody 2F5 from a single device, offering a potential means of protecting women against the transmission of HIV.
Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume77
Issue number1
DOIs
Publication statusPublished - Jan 2011

Bibliographical note

Crown Copyright © 2010. Published by Elsevier B.V. All rights reserved.

ASJC Scopus subject areas

  • Biotechnology
  • Pharmaceutical Science

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