Abstract
Polycomb response elements (PREs) are cis-acting DNA elements that mediate epigenetic gene silencing by Polycomb group (PcG) proteins. Here, we report that Pleiohomeotic (PHO) and a multiprotein Polycomb core complex (PCC) bind highly cooperatively to PREs. We identified a conserved sequence motif, named PCC-binding element (PBE), which is required for PcG silencing in vivo. PHO sites and PBEs function as an integrated DNA platform for the synergistic assembly of a repressive PHO/PCC complex. We termed this nucleoprotein complex silenceosome to reflect that the molecular principles underpinning its assemblage are surprisingly similar to those that make an enhanceosome.
Original language | English |
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Pages (from-to) | 1755-1760 |
Number of pages | 6 |
Journal | Genes and Development |
Volume | 19 |
Issue number | 15 |
DOIs | |
Publication status | Published - 01 Aug 2005 |
Keywords
- Epigenetic silencing
- Pleiohomeotic
- Polycomb
- PRE
- Silenceosome
ASJC Scopus subject areas
- Genetics
- Developmental Biology