Synthesis and antibacterial activity of novel 2-(arylimino)thiazolidin-4-one and 2-(benzylidenehydrazono)-3-arylthiazolidin-4-one derivatives

Ebaa M. El-Hossary, Yassin M. Nissan, Katharina Edkins, Heike Bruhn

Research output: Contribution to journalArticle

1 Citation (Scopus)
75 Downloads (Pure)

Abstract

The ongoing spread of multidrug-resistant bacteria demands an intensive search for new antibacterial agents. In the present study, a series of new 1,3-thiazolidin-4-ones has been synthesized and investigated for its in vitro antibacterial activity. The most potent antibacterial compound 4c was found to be active, at low micromolar range, against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis and the pneumonic plague causative agent Yersinia pestis with minimum inhibitory concentrations of 5 μM, 2.5 μM, 2.5 μM and 5 μM, respectively. Compound 4c showed the ability to kill E. faecalis JH212 strain with a minimum bactericidal concentration of 5 μM. Furthermore, compounds 9b and 10a inhibited the biofilm formation in S. epidermidis, where they showed 70% to 80% inhibition at a concentration of 40 μM.
Original languageEnglish
Pages (from-to)7-17
JournalJournal of Applied Pharmaceutical Science
Volume6
Issue number5
Early online date28 May 2016
DOIs
Publication statusEarly online date - 28 May 2016
Externally publishedYes

Keywords

  • 1,3-Thiazolidin-4-one
  • Antibacterial activity
  • Biofilm formation
  • Minimum bactericidal concentration
  • Minimum inhibitory concentration

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