Synthesis and characterisation of photocrosslinked poly(ethylene glycol) diacrylate
 implants for sustained ocular drug delivery

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Abstract

Purpose
To investigate the sustained ocular delivery of small and large drug molecules from photocrosslinked poly(ethylene glycol) diacrylate (PEGDA) implants with varying pore forming agents.

Methods
Triamcinolone acetonide and ovalbumin loaded photocrosslinked PEGDA implants, with or without pore-forming agents, were fabricated and characterised for chemical, mechanical, swelling, network parameters, as well as drug release and biocompatibility. HPLC-based analytical methods were employed for analysis of two molecules; ELISA was used to demonstrate bioactivity of ovalbumin.

Results
Regardless of PEGDA molecular weight or pore former composition all implants loaded with triamcinolone acetonide released significantly faster than those loaded with ovalbumin. Higher molecular weight PEGDA systems (700 Da) resulted in faster drug release of triamcinolone acetonide than their 250 Da counterpart. All ovalbumin released over the 56-day time period was found to be bioactive. Increasing PEGDA molecular weight resulted in increased system swelling, decreased crosslink density (Ve), increased polymer-water interaction parameter (χ), increased average molecular weight between crosslinks (Mc) and increased mesh size (ε). SEM studies showed the porosity of implants increased with increasing PEGDA molecular weight. Biocompatibility showed both PEGDA molecular weight implants were non-toxic when exposed to retinal epithelial cells over a 7-day period.

Conclusion
Photocrosslinked PEGDA implant based systems are capable of controlled drug release of both small and large drug molecules through adaptations in the polymer system network. We are currently continuing evaluation of these systems as potential sustained drug delivery devices.
Original languageEnglish
Article number36
Number of pages17
JournalPharmaceutical Research
Volume35
Issue number2
Early online date16 Jan 2018
DOIs
Publication statusPublished - Feb 2018

Keywords

  • ocular drug delivery
  • Drug Delivery Systems
  • polymer implant
  • CONTROLLED DRUG-DELIVERY
  • SUSTAINED DELIVERY
  • protein delivery
  • triamcinolone acetonide

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 implants for sustained ocular drug delivery'. Together they form a unique fingerprint.

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