Synthesis and mechanical properties of double cross-linked gelatin-graphene oxide hydrogels

Yongzhe Piao, Biqiong Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


Gelatin is an interesting biological macromolecule for biomedical applications. Here, double cross-linked gelatin nanocomposite hydrogels with incorporation of graphene oxide (GO) were synthesized in one pot using glutaraldehyde (GTA) and GTA-grafted GO as double chemical cross-linkers. The nanocomposite hydrogels, in contrast to the neat gelatin hydrogel, exhibited significant increases in mechanical properties by up to 288% in compressive strength, 195% in compressive modulus, 267% in compressive fracture energy and 160% shear storage modulus with the optimal GO concentration. Fourier transform infrared spectroscopy, scanning electron microscopy and swelling tests were implemented to characterize the nanocomposite hydrogels.

Original languageEnglish
Pages (from-to)791-798
Number of pages8
JournalInternational Journal of Biological Macromolecules
Early online date30 Mar 2017
Publication statusPublished - 01 Aug 2017
Externally publishedYes


  • Gelatin
  • Graphene oxide
  • Mechanical properties
  • Nanocomposite hydrogel

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology


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