Synthesis and release kinetics of polymerisable ester drug conjugates towards pH-responsive infection-resistant urinary biomaterials

Colin P. McCoy*, Nicola J. Irwin, Christopher Brady, David S. Jones, Gavin P. Andrews, Sean P. Gorman

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Herein we report the synthesis, characterisation and hydrolytic release kinetics of a suite of novel, polymerisable ester quinolone conjugates with varying alkenyl chain lengths. Hydrolysis was shown to proceed up to 17-fold faster upon elevation of pH from neutral to pH 9.29, making these conjugates attractive for the development of 'designer' infection-resistant urinary biomaterials exploiting the increase in urine pH reported at the onset of catheter-associated infection to trigger drug release. (C) 2013 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)2511-2514
Number of pages4
JournalTetrahedron Letters
Volume54
Issue number20
DOIs
Publication statusPublished - 15 May 2013

Keywords

  • Chain length
  • pH elevation
  • Ester hydrolysis
  • Drug-polymer conjugates

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