Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)

Richard Williams, K.A. Johnson, P.R. Gentry, C.M. Niswender, C.D. Weaver, P.J. Conn, C.W. Lindsley, C.R. Hopkins

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25 Citations (Scopus)

Abstract

This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson's disease. The synthesis takes advantage of an iterative parallel synthesis approach to rapidly synthesize and evaluate a number of analogs of VU0155041. (C) 2009 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)4967-4970
Number of pages4
JournalBioorganic & Medicinal Chemistry Letters
Volume19
Issue number17
DOIs
Publication statusPublished - 01 Sep 2009

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

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    Williams, R., Johnson, K. A., Gentry, P. R., Niswender, C. M., Weaver, C. D., Conn, P. J., Lindsley, C. W., & Hopkins, C. R. (2009). Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4). Bioorganic & Medicinal Chemistry Letters, 19(17), 4967-4970. https://doi.org/10.1016/j.bmcl.2009.07.072