Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)

Richard Williams; K.A. Johnson; P.R. Gentry; C.M. Niswender; C.D. Weaver; P.J. Conn; C.W. Lindsley; C.R. Hopkins

doi:10.1016/j.bmcl.2009.07.072

Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)

Richard Williams, K.A. Johnson, P.R. Gentry, C.M. Niswender, C.D. Weaver, P.J. Conn, C.W. Lindsley, C.R. Hopkins

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson's disease. The synthesis takes advantage of an iterative parallel synthesis approach to rapidly synthesize and evaluate a number of analogs of VU0155041. (C) 2009 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	4967-4970
Number of pages	4
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	19
Issue number	17
DOIs	https://doi.org/10.1016/j.bmcl.2009.07.072
Publication status	Published - 01 Sep 2009

ASJC Scopus subject areas

Pharmaceutical Science
Drug Discovery
Organic Chemistry
Molecular Medicine
Molecular Biology
Clinical Biochemistry
Biochemistry

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10.1016/j.bmcl.2009.07.072

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title = "Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)",

abstract = "This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson's disease. The synthesis takes advantage of an iterative parallel synthesis approach to rapidly synthesize and evaluate a number of analogs of VU0155041. (C) 2009 Elsevier Ltd. All rights reserved.",

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Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4). / Williams, Richard; Johnson, K.A.; Gentry, P.R.; Niswender, C.M.; Weaver, C.D.; Conn, P.J.; Lindsley, C.W.; Hopkins, C.R.

In: Bioorganic & Medicinal Chemistry Letters, Vol. 19, No. 17, 01.09.2009, p. 4967-4970.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

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AU - Williams, Richard

AU - Johnson, K.A.

AU - Gentry, P.R.

AU - Niswender, C.M.

AU - Weaver, C.D.

AU - Conn, P.J.

AU - Lindsley, C.W.

AU - Hopkins, C.R.

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AB - This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson's disease. The synthesis takes advantage of an iterative parallel synthesis approach to rapidly synthesize and evaluate a number of analogs of VU0155041. (C) 2009 Elsevier Ltd. All rights reserved.

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 17

ER -

Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)

Abstract

ASJC Scopus subject areas

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