Synthesis of 2-Alkynoates by Palladium(II)-Catalyzed Oxidative Carbonylation of Terminal Alkynes and Alcohols

Qun Cao, N. Louise Hughes, Mark J. Muldoon

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Abstract

A homogeneous PdII catalyst, utilizing a simple and inexpensive amine ligand (TMEDA), allows 2-alkynoates to be prepared in high yields by an oxidative carbonylation of terminal alkynes and alcohols. The catalyst system overcomes many of the limitations of previous palladium carbonylation catalysts. It has an increased substrate scope, avoids large excesses of alcohol substrate and uses a desirable solvent. The catalyst employs oxygen as the terminal oxidant and can be operated under safer gas mixtures.
Original languageEnglish
Pages (from-to)11982–11985
JournalChemistry - A European Journal
Volume22
Issue number34
Early online date19 Jul 2016
DOIs
Publication statusPublished - Aug 2016

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