Synthesis of 2-Alkynoates by Palladium(II)-Catalyzed Oxidative Carbonylation of Terminal Alkynes and Alcohols

Qun Cao, N. Louise Hughes, Mark J. Muldoon

Research output: Contribution to journalArticle

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Abstract

A homogeneous PdII catalyst, utilizing a simple and inexpensive amine ligand (TMEDA), allows 2-alkynoates to be prepared in high yields by an oxidative carbonylation of terminal alkynes and alcohols. The catalyst system overcomes many of the limitations of previous palladium carbonylation catalysts. It has an increased substrate scope, avoids large excesses of alcohol substrate and uses a desirable solvent. The catalyst employs oxygen as the terminal oxidant and can be operated under safer gas mixtures.
Original languageEnglish
Pages (from-to)11982–11985
JournalChemistry - A European Journal
Volume22
Issue number34
Early online date19 Jul 2016
DOIs
Publication statusPublished - Aug 2016

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Carbonylation
Alkynes
Palladium
Alcohols
Catalysts
Substrates
Oxidants
Gas mixtures
Amines
Oxygen
Ligands

Cite this

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abstract = "A homogeneous PdII catalyst, utilizing a simple and inexpensive amine ligand (TMEDA), allows 2-alkynoates to be prepared in high yields by an oxidative carbonylation of terminal alkynes and alcohols. The catalyst system overcomes many of the limitations of previous palladium carbonylation catalysts. It has an increased substrate scope, avoids large excesses of alcohol substrate and uses a desirable solvent. The catalyst employs oxygen as the terminal oxidant and can be operated under safer gas mixtures.",
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Synthesis of 2-Alkynoates by Palladium(II)-Catalyzed Oxidative Carbonylation of Terminal Alkynes and Alcohols. / Cao, Qun; Hughes, N. Louise; Muldoon, Mark J. .

In: Chemistry - A European Journal, Vol. 22, No. 34, 08.2016, p. 11982–11985.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis of 2-Alkynoates by Palladium(II)-Catalyzed Oxidative Carbonylation of Terminal Alkynes and Alcohols

AU - Cao, Qun

AU - Hughes, N. Louise

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AB - A homogeneous PdII catalyst, utilizing a simple and inexpensive amine ligand (TMEDA), allows 2-alkynoates to be prepared in high yields by an oxidative carbonylation of terminal alkynes and alcohols. The catalyst system overcomes many of the limitations of previous palladium carbonylation catalysts. It has an increased substrate scope, avoids large excesses of alcohol substrate and uses a desirable solvent. The catalyst employs oxygen as the terminal oxidant and can be operated under safer gas mixtures.

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JF - Chemistry-a European Journal

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