Synthesis of alkylcarbonate analogs of O-acetyl-ADP-ribose

Marcela Dvorakova; Radim Nencka; Milan Dejmek; Eva Zbornikova; Anna Brezinova; Marie Pribylova; Radek Pohl; Marie E. Migaud; Tomas Vanek

doi:10.1039/c3ob41016a

Synthesis of alkylcarbonate analogs of O-acetyl-ADP-ribose

Marcela Dvorakova, Radim Nencka, Milan Dejmek, Eva Zbornikova, Anna Brezinova, Marie Pribylova, Radek Pohl, Marie E. Migaud, Tomas Vanek

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The non-hydrolyzable alkylcarbonate analogs of O-acetyl-ADP-ribose have been synthesized from the phosphorylated ribose derivatives after coupling with AMP morpholidate promoted by mechanical grinding. The analogs were assessed for their ability to inhibit the human sirtuin homolog SIRT1.

Original language	English
Pages (from-to)	5702-5713
Journal	Organic and Biomolecular Chemistry
Volume	11
Issue number	34
Early online date	03 Jul 2013
DOIs	https://doi.org/10.1039/c3ob41016a
Publication status	Published - 14 Sep 2013

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title = "Synthesis of alkylcarbonate analogs of O-acetyl-ADP-ribose",

abstract = "The non-hydrolyzable alkylcarbonate analogs of O-acetyl-ADP-ribose have been synthesized from the phosphorylated ribose derivatives after coupling with AMP morpholidate promoted by mechanical grinding. The analogs were assessed for their ability to inhibit the human sirtuin homolog SIRT1.",

author = "Marcela Dvorakova and Radim Nencka and Milan Dejmek and Eva Zbornikova and Anna Brezinova and Marie Pribylova and Radek Pohl and Migaud, {Marie E.} and Tomas Vanek",

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T1 - Synthesis of alkylcarbonate analogs of O-acetyl-ADP-ribose

AU - Dvorakova, Marcela

AU - Nencka, Radim

AU - Dejmek, Milan

AU - Zbornikova, Eva

AU - Brezinova, Anna

AU - Pribylova, Marie

AU - Pohl, Radek

AU - Migaud, Marie E.

AU - Vanek, Tomas

PY - 2013/9/14

Y1 - 2013/9/14

N2 - The non-hydrolyzable alkylcarbonate analogs of O-acetyl-ADP-ribose have been synthesized from the phosphorylated ribose derivatives after coupling with AMP morpholidate promoted by mechanical grinding. The analogs were assessed for their ability to inhibit the human sirtuin homolog SIRT1.

AB - The non-hydrolyzable alkylcarbonate analogs of O-acetyl-ADP-ribose have been synthesized from the phosphorylated ribose derivatives after coupling with AMP morpholidate promoted by mechanical grinding. The analogs were assessed for their ability to inhibit the human sirtuin homolog SIRT1.

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DO - 10.1039/c3ob41016a

M3 - Article

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EP - 5713

JO - Organic and Biomolecular Chemistry

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