Synthesis of alkylcarbonate analogs of O-acetyl-ADP-ribose

Marcela Dvorakova, Radim Nencka, Milan Dejmek, Eva Zbornikova, Anna Brezinova, Marie Pribylova, Radek Pohl, Marie E. Migaud, Tomas Vanek

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


The non-hydrolyzable alkylcarbonate analogs of O-acetyl-ADP-ribose have been synthesized from the phosphorylated ribose derivatives after coupling with AMP morpholidate promoted by mechanical grinding. The analogs were assessed for their ability to inhibit the human sirtuin homolog SIRT1.
Original languageEnglish
Pages (from-to)5702-5713
JournalOrganic and Biomolecular Chemistry
Issue number34
Early online date03 Jul 2013
Publication statusPublished - 14 Sep 2013

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