Synthesis of an analogue of the bisphosphonate drug Ibandronate for targeted drug-delivery therapeutic strategies

N. Camper, Christopher Scott, Marie Migaud

Research output: Contribution to journalArticle

2 Citations (Scopus)


An analogue of the bisphosphonate drug Ibandronate was prepared and coupled via a cleavable ester function to a bromoacetyl linker with specific reactivity for thiol groups. This compound should find useful applications in therapeutic strategies aiming to deliver bisphosphonate drugs specifically to cancer cells making use of proteins as vectors. The specific delivery of bisphosphonates to cancer cells instead of bone, the usual site of accumulation of these cytotoxic drugs, could greatly widen their therapeutic applications.
Original languageEnglish
Pages (from-to)949-955
Number of pages7
JournalNew journal of chemistry
Issue number5
Publication statusPublished - 2010


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