Synthesis of isomeric polyacetylenes based on natural hydroxy matricaria esters

S. Garrais, J. Turkington, William Goldring

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The construction of a library of natural and related polyacetylenes using a convergent synthetic strategy based on a palladium mediated cross-coupling reaction is described. The systematic synthetic study led to all possible alkene isomers of the hydroxy matricaria esters 29-32, and the corresponding tiglates 1-4. The synthesis of many of these compounds is described for the first time.
Original languageEnglish
Pages (from-to)8418-8427
Number of pages10
JournalTetrahedron
Volume65
Issue number40
DOIs
Publication statusPublished - 03 Oct 2009

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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