Synthesis of (+)-piclavines A1 and A2

H. McAlonan, D. Potts, Paul Stevenson, N. Thompson

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Piclavines AI and A2 have been synthesised for the first time. The route is short with the key step being the reaction of a bicyclic N-acyl iminium ion with 3-trimethysilyl-1-decene. This convergent strategy gave exclusively compounds in which the pendant decenyl group was axial, as a 6:1 mixture of E:Z-alkene diastereoisomers. Reduction of the lactam carbonyl group gave a 6:1 mixture of piclavines Al and A2, (C) 2000 Published by Elsevier Science Ltd.
Original languageEnglish
Pages (from-to)5411-5414
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number28
Publication statusPublished - 08 Dec 2000

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Fingerprint

Dive into the research topics of 'Synthesis of (+)-piclavines A1 and A2'. Together they form a unique fingerprint.

Cite this