A novel approach to diene based quinolizidines, using an intramolecular Heck reaction in which the vinyl bromide double bond undergoes inversion of configuration, is reported. These quinolizidines have previously been proposed as tentative structures for homopumiliotoxin alkaloids 233F and 235C. The mass spectral data of the synthetic materials were different to those of the natural products confirming that the original structures need to be revised. (C) 2004 Elsevier Ltd. All rights reserved.
ASJC Scopus subject areas
- Organic Chemistry
- Drug Discovery
Armstrong, P., Feutren, S., McAlonan, H., O'Mahony, G., & Stevenson, P. (2004). Synthesis of the putative structures of homopumiliotoxins 235C and 233F. Tetrahedron Letters, 45(8), 1627-1630. https://doi.org/10.1016/j.tetlet.2003.12.126