Synthesis of the putative structures of homopumiliotoxins 235C and 233F

P. Armstrong, S. Feutren, H. McAlonan, G. O'Mahony, Paul Stevenson

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A novel approach to diene based quinolizidines, using an intramolecular Heck reaction in which the vinyl bromide double bond undergoes inversion of configuration, is reported. These quinolizidines have previously been proposed as tentative structures for homopumiliotoxin alkaloids 233F and 235C. The mass spectral data of the synthetic materials were different to those of the natural products confirming that the original structures need to be revised. (C) 2004 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)1627-1630
Number of pages4
JournalTetrahedron Letters
Volume45
Issue number8
DOIs
Publication statusPublished - 16 Feb 2004

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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