Systematic reviews and randomised controlled trials on open angle glaucoma

Richard Wormald*, Gianni Virgili, Augusto Azuara-Blanco

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)


Evidence for the effectiveness of interventions to prevent the progression of optic nerve damage in open angle glaucoma has evolved over the last 25 years. We describe that evolution through the systematic reviews on various aspects of the topic and how those reviews have highlighted the need for new trials. Though we can be confident that lowering pressure does indeed reduce the risk of progression, we still lack good evidence on the comparative effectiveness of different treatments not so much on lowering pressure but on preventing progression of the disease. This is true for different medicines, types of laser and especially for different surgical interventions. As always there is a need for more research, but this needs to be focussed on key uncertainties using core outcome sets which avoid research waste. Ultimately, our guidelines can be based on sound and comprehensive evidence of effectiveness.

Original languageEnglish
Pages (from-to)161-167
Number of pages7
JournalEye (Basingstoke)
Issue number1
Early online date03 Dec 2019
Publication statusPublished - 01 Jan 2020

Bibliographical note

Funding Information:
Funding RW is funded by the Department of Health through the award made by the National Institute for Health Research to Moor-fields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology for a Specialist Biomedical Research Centre for Ophthalmology. The views expressed in this publication are those of the authors and not necessarily those of the Department of Health.

Publisher Copyright:
© 2019, The Author(s), under exclusive licence to The Royal College of Ophthalmologists.

Copyright 2020 Elsevier B.V., All rights reserved.

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems


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