TY - JOUR
T1 - Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population
AU - Mauschitz, Matthias M.
AU - Bonnemaijer, Pieter W.M.
AU - Diers, Kersten
AU - Rauscher, Franziska G.
AU - Elze, Tobias
AU - Engel, Christoph
AU - Loeffler, Markus
AU - Colijn, Johanna Maria
AU - Ikram, M. Arfan
AU - Vingerling, Johannes R.
AU - Williams, Katie
AU - Hammond, Christopher
AU - Creuzot-Garcher, Catherine
AU - Bron, Alain M.
AU - Silva, Rufino
AU - Nunes, Sandrina
AU - Delcourt, Cécile
AU - Cougnard-Grégoire, Audrey
AU - Holz, Frank
AU - Klaver, Caroline
AU - Breteler, Monique M.B.
AU - Finger, Robert P.
AU - Acar, Niyazi
AU - Anastosopoulos, Eleftherios
AU - Azuara-Blanco, Augusto
AU - Berendschot, Tos
AU - Bergen, Arthur
AU - Bertelsen, Geir
AU - Binquet, Christine
AU - Bird, Alan
AU - Bobak, Martin
AU - Larsen, Morten Bøgelund
AU - Boon, Camiel
AU - Bourne, Rupert
AU - Brétillon, Lionel
AU - Broe, Rebecca
AU - Bron, Alain
AU - Buitendijk, Gabrielle
AU - Cachulo, Maria Luz
AU - Capuano, Vittorio
AU - Carrière, Isabelle
AU - Chakravarthy, Usha
AU - Chan, Michelle
AU - Chang, Petrus
AU - Colijn, Johanna
AU - Foster, Paul
AU - Hogg, Ruth
AU - Muldrew, Alyson
AU - Peto, Tunde
AU - Silvestri, Giuliana
AU - European Eye Epidemiology (E3) Consortium
PY - 2018/4/30
Y1 - 2018/4/30
N2 - Purpose: To investigate systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness (pRNFLT) in the European population. Design: Cross-sectional meta-analysis. Participants: A total of 16 084 European adults from 8 cohort studies (mean age range, 56.9±12.3–82.1±4.2 years) of the European Eye Epidemiology (E3) consortium. Methods: We examined associations with pRNFLT measured by spectral-domain OCT in each study using multivariable linear regression and pooled results using random effects meta-analysis. Main Outcome Measures: Determinants of pRNFLT. Results: Mean pRNFLT ranged from 86.8±21.4 μm in the Rotterdam Study I to 104.7±12.5 μm in the Rotterdam Study III. We found the following factors to be associated with reduced pRNFLT: Older age (β = –0.38 μm/year; 95% confidence interval [CI], –0.57 to –0.18), higher intraocular pressure (IOP) (β = –0.36 μm/mmHg; 95% CI, –0.56 to –0.15), visual impairment (β = –5.50 μm; 95% CI, –9.37 to –1.64), and history of systemic hypertension (β = –0.54 μm; 95% CI, –1.01 to –0.07) and stroke (β = –1.94 μm; 95% CI, –3.17 to –0.72). A suggestive, albeit nonsignificant, association was observed for dementia (β = –3.11 μm; 95% CI, –6.22 to 0.01). Higher pRNFLT was associated with more hyperopic spherical equivalent (β = 1.39 μm/diopter; 95% CI, 1.19–1.59) and smoking (β = 1.53 μm; 95% CI, 1.00–2.06 for current smokers compared with never-smokers). Conclusions: In addition to previously described determinants such as age and refraction, we found that systemic vascular and neurovascular diseases were associated with reduced pRNFLT. These may be of clinical relevance, especially in glaucoma monitoring of patients with newly occurring vascular comorbidities.
AB - Purpose: To investigate systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness (pRNFLT) in the European population. Design: Cross-sectional meta-analysis. Participants: A total of 16 084 European adults from 8 cohort studies (mean age range, 56.9±12.3–82.1±4.2 years) of the European Eye Epidemiology (E3) consortium. Methods: We examined associations with pRNFLT measured by spectral-domain OCT in each study using multivariable linear regression and pooled results using random effects meta-analysis. Main Outcome Measures: Determinants of pRNFLT. Results: Mean pRNFLT ranged from 86.8±21.4 μm in the Rotterdam Study I to 104.7±12.5 μm in the Rotterdam Study III. We found the following factors to be associated with reduced pRNFLT: Older age (β = –0.38 μm/year; 95% confidence interval [CI], –0.57 to –0.18), higher intraocular pressure (IOP) (β = –0.36 μm/mmHg; 95% CI, –0.56 to –0.15), visual impairment (β = –5.50 μm; 95% CI, –9.37 to –1.64), and history of systemic hypertension (β = –0.54 μm; 95% CI, –1.01 to –0.07) and stroke (β = –1.94 μm; 95% CI, –3.17 to –0.72). A suggestive, albeit nonsignificant, association was observed for dementia (β = –3.11 μm; 95% CI, –6.22 to 0.01). Higher pRNFLT was associated with more hyperopic spherical equivalent (β = 1.39 μm/diopter; 95% CI, 1.19–1.59) and smoking (β = 1.53 μm; 95% CI, 1.00–2.06 for current smokers compared with never-smokers). Conclusions: In addition to previously described determinants such as age and refraction, we found that systemic vascular and neurovascular diseases were associated with reduced pRNFLT. These may be of clinical relevance, especially in glaucoma monitoring of patients with newly occurring vascular comorbidities.
UR - http://www.scopus.com/inward/record.url?scp=85046169497&partnerID=8YFLogxK
U2 - 10.1016/j.ophtha.2018.03.026
DO - 10.1016/j.ophtha.2018.03.026
M3 - Article
AN - SCOPUS:85046169497
SN - 0161-6420
JO - Ophthalmology
JF - Ophthalmology
ER -