Systemic chemokine levels, coronary heart disease, and ischemic stroke events: The PRIME Study

F. Canoui-Poitrine, G. Luc, Z. Mallat, E. Machfez, A. Bingham, J. Ferrieres, J.B. Ruidavets, M. Montaye, J. Yarnell, B. Haas, D. Arveiler, P. Morange, F. Kee, A. Evans, P. Amouyel, P. Ducimetiere, J.P. Empana

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)
151 Downloads (Pure)

Abstract

Objectives: To quantify the association between systemic levels of the chemokine regulated on activation normal T-cell expressed and secreted (RANTES/CCL5), interferon-γ-inducible protein-10 (IP-10/CXCL10), monocyte chemoattractant protein-1 (MCP-1/CCL2), and eotaxin-1 (CCL11) with future coronary heart disease (CHD) and ischemic stroke events and to assess their usefulness for CHD and ischemic stroke risk prediction in the PRIME Study.

Methods: After 10 years of follow-up of 9,771 men, 2 nested case-control studies were built including 621 first CHD events and 1,242 matched controls and 95 first ischemic stroke events and 190 matched controls. Standardized hazard ratios (HRs) for each log-transformed chemokine were estimated by conditional logistic regression.

Results: None of the 4 chemokines were independent predictors of CHD, either with respect to stable angina or to acute coronary syndrome. Conversely, RANTES (HR = 1.70; 95% confidence interval [CI] 1.05–2.74), IP-10 (HR = 1.53; 95% CI 1.06–2.20), and eotaxin-1 (HR = 1.59; 95% CI 1.02–2.46), but not MCP-1 (HR = 0.99; 95% CI 0.68–1.46), were associated with ischemic stroke independently of traditional cardiovascular risk factors, hs-CRP, and fibrinogen. When the first 3 chemokines were included in the same multivariate model, RANTES and IP-10 remained predictive of ischemic stroke. Their addition to a traditional risk factor model predicting ischemic stroke substantially improved the C-statistic from 0.6756 to 0.7425 (p = 0.004).

Conclusions: In asymptomatic men, higher systemic levels of RANTES and IP-10 are independent predictors of ischemic stroke but not of CHD events. RANTES and IP-10 may improve the accuracy of ischemic stroke risk prediction over traditional risk factors.
Original languageEnglish
Pages (from-to)1165-1173
JournalNeurology
Volume77
Issue number12
Early online date17 Aug 2011
DOIs
Publication statusPublished - 20 Sept 2011

Bibliographical note

Unrecognised author: 'PRIME Study Group'

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Fingerprint

Dive into the research topics of 'Systemic chemokine levels, coronary heart disease, and ischemic stroke events: The PRIME Study'. Together they form a unique fingerprint.

Cite this