Systemic inflammation and the relationship between periodontitis, edentulism and all‐cause mortality: a 17‐year prospective cohort study

Lewis Winning, Christopher C. Patterson, Katie Linden, Kathy M. Cullen, Frank Kee, Gerard J. Linden

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The aim was to investigate the role of systemic inflammation in the relationship between periodontitis, edentulism and all-cause mortality in a group of men in Northern Ireland aged 58–72 years.

Methods: A representative sample of 1558 men had a detailed dental examination between 2001 and 2003. The primary end point was death from any cause. Cox's proportional hazards model was used to assess the longitudinal relationship between periodontitis, edentulism and all-cause mortality. Accelerated failure time modelling was performed to investigate the mediating role of systemic inflammation.

Results: Mean age of the men at baseline was 64.3 (SD 2.9) years. During a median follow-up of 17 years, 500 (32.1%) men died. After adjustment for confounding variables, compared to men with no/mild periodontitis, the hazard ratio for all-cause mortality amongst edentulous men was 1.52 (95% CI 1.16-1.99) p<0.01, and for those with severe periodontitis was 1.34 (95% CI 1.06-1.70) p=0.01. Systemic inflammation only accounted for a minor mediating pathway effect of 10%.

Conclusion: There was evidence in this group of men, that those who were edentulous or had severe periodontitis had a significantly increased risk of all-cause mortality. Systemic inflammation was not a major explanatory mediator of this association.
Original languageEnglish
JournalJournal of Clinical Periodontology
Early online date09 Jun 2021
DOIs
Publication statusEarly online date - 09 Jun 2021

Keywords

  • Periodontics

Fingerprint

Dive into the research topics of 'Systemic inflammation and the relationship between periodontitis, edentulism and all‐cause mortality: a 17‐year prospective cohort study'. Together they form a unique fingerprint.

Cite this