Systemic mastocytosis with an abnormally expanded t-cell clone

M. F. Mcmullin; M. Chapple; T. Vulliamy; D. M. Swirsky; A. J. Barrett; P. A. Thorpe; R. G. Hughes

doi:10.3109/10428199209053576

Systemic mastocytosis with an abnormally expanded t-cell clone

M. F. Mcmullin^*, M. Chapple, T. Vulliamy, D. M. Swirsky, A. J. Barrett, P. A. Thorpe, R. G. Hughes

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A patient with aggressive systemic mastocytosis was found to have a clonal T lymphocyte disorder using T cell receptor gene rearrangement studies. There was some response to intensive chemotherapy initially and later alpha interferon achieved partial disease control. This case suggests the possibility that a malignant T lymphoproliferative disorder producing mast cell growth factors is the underlying cause of some cases of systemic mastocytosis.

Original language	English
Pages (from-to)	419-422
Number of pages	4
Journal	Leukemia and Lymphoma
Volume	6
Issue number	4-5
DOIs	https://doi.org/10.3109/10428199209053576
Publication status	Published - 01 Jan 1992
Externally published	Yes

Keywords

Alpha interferon
Gene rearrangements
Systemic mastocytosis

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/10428199209053576

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title = "Systemic mastocytosis with an abnormally expanded t-cell clone",

abstract = "A patient with aggressive systemic mastocytosis was found to have a clonal T lymphocyte disorder using T cell receptor gene rearrangement studies. There was some response to intensive chemotherapy initially and later alpha interferon achieved partial disease control. This case suggests the possibility that a malignant T lymphoproliferative disorder producing mast cell growth factors is the underlying cause of some cases of systemic mastocytosis.",

keywords = "Alpha interferon, Gene rearrangements, Systemic mastocytosis",

author = "Mcmullin, {M. F.} and M. Chapple and T. Vulliamy and Swirsky, {D. M.} and Barrett, {A. J.} and Thorpe, {P. A.} and Hughes, {R. G.}",

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T1 - Systemic mastocytosis with an abnormally expanded t-cell clone

AU - Mcmullin, M. F.

AU - Chapple, M.

AU - Vulliamy, T.

AU - Swirsky, D. M.

AU - Barrett, A. J.

AU - Thorpe, P. A.

AU - Hughes, R. G.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - A patient with aggressive systemic mastocytosis was found to have a clonal T lymphocyte disorder using T cell receptor gene rearrangement studies. There was some response to intensive chemotherapy initially and later alpha interferon achieved partial disease control. This case suggests the possibility that a malignant T lymphoproliferative disorder producing mast cell growth factors is the underlying cause of some cases of systemic mastocytosis.

AB - A patient with aggressive systemic mastocytosis was found to have a clonal T lymphocyte disorder using T cell receptor gene rearrangement studies. There was some response to intensive chemotherapy initially and later alpha interferon achieved partial disease control. This case suggests the possibility that a malignant T lymphoproliferative disorder producing mast cell growth factors is the underlying cause of some cases of systemic mastocytosis.

KW - Alpha interferon

KW - Gene rearrangements

KW - Systemic mastocytosis

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U2 - 10.3109/10428199209053576

DO - 10.3109/10428199209053576

M3 - Article

AN - SCOPUS:0026562968

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VL - 6

SP - 419

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JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

IS - 4-5

ER -

Systemic mastocytosis with an abnormally expanded t-cell clone

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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