Systemic mastocytosis with an abnormally expanded t-cell clone

M. F. Mcmullin*, M. Chapple, T. Vulliamy, D. M. Swirsky, A. J. Barrett, P. A. Thorpe, R. G. Hughes

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


A patient with aggressive systemic mastocytosis was found to have a clonal T lymphocyte disorder using T cell receptor gene rearrangement studies. There was some response to intensive chemotherapy initially and later alpha interferon achieved partial disease control. This case suggests the possibility that a malignant T lymphoproliferative disorder producing mast cell growth factors is the underlying cause of some cases of systemic mastocytosis.

Original languageEnglish
Pages (from-to)419-422
Number of pages4
JournalLeukemia and Lymphoma
Issue number4-5
Publication statusPublished - 01 Jan 1992
Externally publishedYes


  • Alpha interferon
  • Gene rearrangements
  • Systemic mastocytosis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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