Systems analysis of the prostate transcriptome in African-American men compared with European-American men

Gary Hardiman; Stephen J. Savage; E. Starr Hazard; Robert C. Wilson; Sean M. Courtney; Michael T. Smith; Bruce W. Hollis; Chanita Hughes Halbert; Sebastiano Gattoni-Celli

doi:10.2217/pgs-2016-0025

Systems analysis of the prostate transcriptome in African-American men compared with European-American men

Gary Hardiman^*, Stephen J. Savage, E. Starr Hazard, Robert C. Wilson, Sean M. Courtney, Michael T. Smith, Bruce W. Hollis, Chanita Hughes Halbert, Sebastiano Gattoni-Celli

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

Abstract

Aim: African-Americans (AA) have increased prostate cancer risk and a greater mortality rate than European-Americans (EA). AA exhibit a high prevalence of vitamin D deficiency. We examined the global prostate transcriptome in AA and EA, and the effect of vitamin D ₃ supplementation. Patients & methods: Twenty-seven male subjects (ten AA and 17 EA), slated to undergo prostatectomy were enrolled in the study. Fourteen subjects received vitamin D ₃ (4000 IU daily) and 13 subjects received placebo for 2 months prior to surgery. Results: AA show higher expression of genes associated with immune response and inflammation. Conclusion: Systems level analyses support the concept that Inflammatory processes may contribute to disease progression in AA. These transcripts can be modulated by a short course of vitamin D ₃ supplementation.

Original language	English
Pages (from-to)	1129-1143
Journal	Pharmacogenomics
Volume	17
Issue number	10
DOIs	https://doi.org/10.2217/pgs-2016-0025
Publication status	Published - 30 Jun 2016
Externally published	Yes

Keywords

African-American
health disparities
prostate
RNA-seq
transcription
Vitamin D

ASJC Scopus subject areas

Molecular Medicine
Genetics
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.2217/pgs-2016-0025Licence: Unspecified

Cite this

@article{36ab5d3cb05a45f6ad393b64ee19c79d,

title = "Systems analysis of the prostate transcriptome in African-American men compared with European-American men",

abstract = " Aim: African-Americans (AA) have increased prostate cancer risk and a greater mortality rate than European-Americans (EA). AA exhibit a high prevalence of vitamin D deficiency. We examined the global prostate transcriptome in AA and EA, and the effect of vitamin D 3 supplementation. Patients & methods: Twenty-seven male subjects (ten AA and 17 EA), slated to undergo prostatectomy were enrolled in the study. Fourteen subjects received vitamin D 3 (4000 IU daily) and 13 subjects received placebo for 2 months prior to surgery. Results: AA show higher expression of genes associated with immune response and inflammation. Conclusion: Systems level analyses support the concept that Inflammatory processes may contribute to disease progression in AA. These transcripts can be modulated by a short course of vitamin D 3 supplementation. ",

keywords = "African-American, health disparities, prostate, RNA-seq, transcription, Vitamin D",

author = "Gary Hardiman and Savage, {Stephen J.} and Hazard, {E. Starr} and Wilson, {Robert C.} and Courtney, {Sean M.} and Smith, {Michael T.} and Hollis, {Bruce W.} and Halbert, {Chanita Hughes} and Sebastiano Gattoni-Celli",

year = "2016",

month = jun,

day = "30",

doi = "10.2217/pgs-2016-0025",

language = "English",

volume = "17",

pages = "1129--1143",

journal = "Pharmacogenomics",

issn = "1462-2416",

publisher = "Future Medicine Ltd.",

number = "10",

}

TY - JOUR

T1 - Systems analysis of the prostate transcriptome in African-American men compared with European-American men

AU - Hardiman, Gary

AU - Savage, Stephen J.

AU - Hazard, E. Starr

AU - Wilson, Robert C.

AU - Courtney, Sean M.

AU - Smith, Michael T.

AU - Hollis, Bruce W.

AU - Halbert, Chanita Hughes

AU - Gattoni-Celli, Sebastiano

PY - 2016/6/30

Y1 - 2016/6/30

N2 - Aim: African-Americans (AA) have increased prostate cancer risk and a greater mortality rate than European-Americans (EA). AA exhibit a high prevalence of vitamin D deficiency. We examined the global prostate transcriptome in AA and EA, and the effect of vitamin D 3 supplementation. Patients & methods: Twenty-seven male subjects (ten AA and 17 EA), slated to undergo prostatectomy were enrolled in the study. Fourteen subjects received vitamin D 3 (4000 IU daily) and 13 subjects received placebo for 2 months prior to surgery. Results: AA show higher expression of genes associated with immune response and inflammation. Conclusion: Systems level analyses support the concept that Inflammatory processes may contribute to disease progression in AA. These transcripts can be modulated by a short course of vitamin D 3 supplementation.

AB - Aim: African-Americans (AA) have increased prostate cancer risk and a greater mortality rate than European-Americans (EA). AA exhibit a high prevalence of vitamin D deficiency. We examined the global prostate transcriptome in AA and EA, and the effect of vitamin D 3 supplementation. Patients & methods: Twenty-seven male subjects (ten AA and 17 EA), slated to undergo prostatectomy were enrolled in the study. Fourteen subjects received vitamin D 3 (4000 IU daily) and 13 subjects received placebo for 2 months prior to surgery. Results: AA show higher expression of genes associated with immune response and inflammation. Conclusion: Systems level analyses support the concept that Inflammatory processes may contribute to disease progression in AA. These transcripts can be modulated by a short course of vitamin D 3 supplementation.

KW - African-American

KW - health disparities

KW - prostate

KW - RNA-seq

KW - transcription

KW - Vitamin D

UR - http://www.scopus.com/inward/record.url?scp=84979582168&partnerID=8YFLogxK

U2 - 10.2217/pgs-2016-0025

DO - 10.2217/pgs-2016-0025

M3 - Article

C2 - 27359067

AN - SCOPUS:84979582168

SN - 1462-2416

VL - 17

SP - 1129

EP - 1143

JO - Pharmacogenomics

JF - Pharmacogenomics

IS - 10

ER -

Systems analysis of the prostate transcriptome in African-American men compared with European-American men

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this