Systems analysis of the prostate transcriptome in African-American men compared with European-American men

Gary Hardiman*, Stephen J. Savage, E. Starr Hazard, Robert C. Wilson, Sean M. Courtney, Michael T. Smith, Bruce W. Hollis, Chanita Hughes Halbert, Sebastiano Gattoni-Celli

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Aim: African-Americans (AA) have increased prostate cancer risk and a greater mortality rate than European-Americans (EA). AA exhibit a high prevalence of vitamin D deficiency. We examined the global prostate transcriptome in AA and EA, and the effect of vitamin D 3 supplementation. Patients & methods: Twenty-seven male subjects (ten AA and 17 EA), slated to undergo prostatectomy were enrolled in the study. Fourteen subjects received vitamin D 3 (4000 IU daily) and 13 subjects received placebo for 2 months prior to surgery. Results: AA show higher expression of genes associated with immune response and inflammation. Conclusion: Systems level analyses support the concept that Inflammatory processes may contribute to disease progression in AA. These transcripts can be modulated by a short course of vitamin D 3 supplementation.

Original languageEnglish
Pages (from-to)1129-1143
JournalPharmacogenomics
Volume17
Issue number10
DOIs
Publication statusPublished - 30 Jun 2016
Externally publishedYes

Keywords

  • African-American
  • health disparities
  • prostate
  • RNA-seq
  • transcription
  • Vitamin D

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

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