We describe a malignant lymphoma of the parotid gland arising in a patient with Sjögren's syndrome. Diagnosis was established on needle biopsy which showed a mixed population of lymphoid cells. Immunohistochemistry revealed B-lymphoid cells, T-lymphoid cells and histiocytes. Clonal immunoglobulin heavy chain gene rearrangement was demonstrated using the polymerase chain reaction. Within the confines of the small biopsy, the lesion qualifies for the designation T-cell-rich histiocyte-rich B-cell lymphoma. The value of molecular techniques in the diagnosis of malignant lymphoma on limited tissue samples is highlighted by this case.
McCluggage, W. G., McManus, D., Maxwell, P., & Walsh, M. Y. (1996). T-cell-rich histiocyte-rich B-cell lymphoma of parotid gland. Journal of Laryngology and Otology, 110(8), 811-813. https://doi.org/10.1017/S0022215100135042