Tailoring Plasmonic Metamaterials for Ultrasenstive Detection of Mercury Trace Contaminants via Molecular Logic Gates

Research output: Contribution to conferencePosterpeer-review

Abstract

Structural and functional information encoded in DNA combined with unique properties of nanomaterials could be of use for the construction of novel biocomputational circuits and intelligent biomedical nanodevices. However, at present their practical applications are still limited by either low reproducibility of fabrication, modest sensitivity, or complicated handling procedures. Here, we demonstrate the construction of label-free and switchable molecular logic gates (AND, INHIBIT, and OR) that use specific conformation modulation of a guanine- and thymine-rich DNA, while the optical readout is enabled by the tunable metamaterials which serve as a substrate for surface enhanced Raman spectroscopy (MetaSERS). Our MetaSERS-based DNA logic is simple to operate, highly reproducible, and can be stimulated by ultra-low concentration of the external inputs, enabling an extremely sensitive detection of mercury ions down to 2×10-4 ppb, which is four orders of magnitude lower than the exposure limit allowed by United States Environmental Protection Agency
Original languageEnglish
Publication statusPublished - 2014
EventASSET 2014: Food Integrity and Traceability Conference - Queen's University Belfast, Belfast, United Kingdom
Duration: 08 Apr 201410 Apr 2014

Conference

ConferenceASSET 2014: Food Integrity and Traceability Conference
CountryUnited Kingdom
CityBelfast
Period08/04/201410/04/2014

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