Tau acts as an independent genetic risk factor in pathologically proven PD

Gavin Charlesworth, Sonia Gandhi, Jose M. Bras, Roger A. Barker, David J. Burn, Patrick F. Chinnery, Stephen M. Gentleman, Rita Guerreiro, John Hardy, Janice L. Holton, Andrew Lees, Karen Morrison, Una-Marie Sheerin, Nigel Williams, Huw Morris, Tamas Revesz, Nicholas W. Wood

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

MAPT has been repeatedly linked with Parkinson's disease (PD) in association studies. Although tau deposition may be seen in PD, its relevance to the pathogenesis of the condition remains unclear. The presence of tau-positive inclusions is, however, the defining feature of progressive supranuclear palsy (PSP), which may often be clinically misdiagnosed as idiopathic PD. On a genetic level, variants in MAPT are the strongest risk factor for PSP. These facts raise the question whether the MAPT association in PD results from contamination with unrecognized cases of PSP. Using only neuropathologically proven PD, we show that the MAPT association remains and is independent of the PSP Association.
Original languageEnglish
Pages (from-to)838.e7-838.e11
JournalNeurobiology of Aging
Volume33
Issue number4
DOIs
Publication statusPublished - 01 Apr 2012

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