Taxonomic position, antibiotic resistance and virulence factors of clinical Achromobacter isolates

Ad C Fluit, Jumamurat R Bayjanov, María Díez Aguilar, Barry Benaissa-Trouw, Michael M Tunney, Mireille van Westreenen, Jacques F Meis, J Stuart Elborn, Rafael Cantón, Miquel B Ekkelenkamp

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
45 Downloads (Pure)


The role of species in lung disease remains unclear. The aim of this study was to characterize isolated from persons with cystic fibrosis and from other clinical samples. Whole genome sequences from 101 isolates were determined (81 from patients with cystic fibrosis and 20 from other patients) and analysed. Taxonomic analysis showed nine species including two putative novel species. Thirty-five novel sequence types were present. The most active agent was co-trimoxazole followed by imipenem, but Minimal Inhibitory Concentrations (MICs) were high. Acquired antibiotic resistance genes were rare. Their presence did not correlate with minimal inhibitory concentrations suggesting that other mechanisms are involved. Genes for proposed virulence factors were present in only some isolates. Two putative novel species were identified. The putative virulence properties of involved in infections are variable. Despite the high MICs, acquired resistance genes are uncommon.
Original languageEnglish
Article number9
JournalFrontiers in bioscience (Scholar edition)
Issue number2
Publication statusPublished - 21 Mar 2022


  • Gram-Negative Bacterial Infections - drug therapy
  • Anti-Bacterial Agents - pharmacology - therapeutic use
  • virulence
  • Virulence Factors - genetics
  • antibiotic resistance
  • Humans
  • Achromobacter - genetics
  • cystic fibrosis
  • taxonomy
  • Cystic Fibrosis - drug therapy
  • Drug Resistance, Microbial


Dive into the research topics of 'Taxonomic position, antibiotic resistance and virulence factors of clinical Achromobacter isolates'. Together they form a unique fingerprint.

Cite this