Teaching the physiology of adaptation to hypoxic stress with the aid of a classic paper on high altitude by Houston and Riley

Etain A. Tansey*

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Many pathological conditions exist where tissues exhibit hypoxia or low oxygen tension. Hypoxic hypoxia arises when there is a reduction in the amount of oxygen entering the blood and occurs in healthy people at high altitude. In 1946, research sponsored by the United States Navy led to the collection and subsequent publication of masses of data demonstrating the physiological consequences and adaptations of ascent to high altitude. This article describes how a figure from a 1947 paper from the American Physiological Society Legacy collection (Houston CS, Riley RL. Respiratory and circulatory changes during acclimatization to high altitude. Am J Physiol 149: 565-588) may be used to allow students to review their understanding of some of the generalized effects of hypoxia on the body. In particular, this figure summarizes some of the adaptive responses that take place in the oxygen transport system as a consequence of prolonged hypoxia.

Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalAdvances in Physiology Education
Volume32
Issue number1
DOIs
Publication statusPublished - Mar 2008

Keywords

  • hypoxia
  • oxygen transport system
  • education
  • PULMONARY GAS-EXCHANGE
  • OPERATION EVEREST-II
  • EXTREME ALTITUDE
  • ACCLIMATIZATION

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