Tegument and external Features of Schistosoma (with particular reference to ultrastructure)

Geoffrey N. Gobert*, Leigh Schulte, Malcolm K. Jones

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

The integument (hereafter tegument) of adult and larval schistosomes has attracted substantial interest from the schistosomiasis research community. This thin layer, approximately 1-5 μm thick, is the primary physical delineating interface of the parasite, with other borders being the lining of the internal digestive canal (Wilson and Xiaohong Li, Chapter 11), the excretory system (Kusel, Chapter 16) and the reproductive system (Jones et al., Chapter 13). This syncytial layer provokes interest because it is considered a primary target for drug and vaccine studies (Loukas et al. 2007). Further, the interest arises from the intense remodeling of the layer that occurs as the parasite invades a new host (Hockley and McLaren 1973), because of multifaceted functions (Skelly and Wilson 2006) and exquisite structure. In this chapter, we will examine each of these relevant facets and will build on the strong structural knowledge that commenced during the 1960’s and 1970’s corresponding with the expansion of electron microscopy techniques for biological applications. The tegument has been the subject of numerous reviews (Hockley 1973; Hockley and McLaren 1973; Jones et al. 2004; Kusel et al. 2007; Loukas et al. 2007; Skelly and Wilson 2006; Wilson 2012a, 2012b) among many others) and the reader is referred to these others for further details and structural and functional aspects of the tissue.

Original languageEnglish
Title of host publicationSchistosoma
Subtitle of host publicationBiology, Pathology and Control
PublisherCRC Press
Pages213-238
Number of pages26
ISBN (Electronic)9781498744263
ISBN (Print)9781498744256
DOIs
Publication statusPublished - 01 Jan 2017

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Fingerprint Dive into the research topics of 'Tegument and external Features of Schistosoma (with particular reference to ultrastructure)'. Together they form a unique fingerprint.

  • Cite this

    Gobert, G. N., Schulte, L., & Jones, M. K. (2017). Tegument and external Features of Schistosoma (with particular reference to ultrastructure). In Schistosoma: Biology, Pathology and Control (pp. 213-238). CRC Press. https://doi.org/10.1201/9781315368900