Telmisartan to prevent recurrent stroke and cardiovascular events

Salim Yusuf; Hans-Christoph Diener; Ralph L Sacco; Daniel Cotton; Stephanie Ounpuu; William A Lawton; Yuko Palesch; Reneé H Martin; Gregory W Albers; Philip Bath; Natan Bornstein; Bernard P L Chan; Sien-Tsong Chen; Luis Cunha; Björn Dahlöf; Jacques De Keyser; Geoffrey A Donnan; Conrado Estol; Philip Gorelick; Vivian Gu; Karin Hermansson; Lutz Hilbrich; Markku Kaste; Chuanzhen Lu; Thomas Machnig; Prem Pais; Robin Roberts; Veronika Skvortsova; Philip Teal; Danilo Toni; Cam VanderMaelen; Thor Voigt; Michael Weber; Byung-Woo Yoon; PRoFESS Study Group; Peter Passmore

doi:10.1056/NEJMoa0804593

Telmisartan to prevent recurrent stroke and cardiovascular events

Salim Yusuf, Hans-Christoph Diener, Ralph L Sacco, Daniel Cotton, Stephanie Ounpuu, William A Lawton, Yuko Palesch, Reneé H Martin, Gregory W Albers, Philip Bath, Natan Bornstein, Bernard P L Chan, Sien-Tsong Chen, Luis Cunha, Björn Dahlöf, Jacques De Keyser, Geoffrey A Donnan, Conrado Estol, Philip Gorelick, Vivian GuKarin Hermansson, Lutz Hilbrich, Markku Kaste, Chuanzhen Lu, Thomas Machnig, Prem Pais, Robin Roberts, Veronika Skvortsova, Philip Teal, Danilo Toni, Cam VanderMaelen, Thor Voigt, Michael Weber, Byung-Woo Yoon, PRoFESS Study Group, Peter Passmore

Research output: Contribution to journal › Article › peer-review

587 Citations (Scopus)

Abstract

Prolonged lowering of blood pressure after a stroke reduces the risk of recurrent stroke. In addition, inhibition of the renin-angiotensin system in high-risk patients reduces the rate of subsequent cardiovascular events, including stroke. However, the effect of lowering of blood pressure with a renin-angiotensin system inhibitor soon after a stroke has not been clearly established. We evaluated the effects of therapy with an angiotensin-receptor blocker, telmisartan, initiated early after a stroke.

Original language	English
Pages (from-to)	1225-37
Number of pages	13
Journal	New England Journal of Medicine
Volume	359
Issue number	12
DOIs	https://doi.org/10.1056/NEJMoa0804593
Publication status	Published - 18 Sep 2008

ASJC Scopus subject areas

Medicine(all)

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Yusuf, S., Diener, H-C., Sacco, R. L., Cotton, D., Ounpuu, S., Lawton, W. A., Palesch, Y., Martin, R. H., Albers, G. W., Bath, P., Bornstein, N., Chan, B. P. L., Chen, S-T., Cunha, L., Dahlöf, B., De Keyser, J., Donnan, G. A., Estol, C., Gorelick, P., ... Passmore, P. (2008). Telmisartan to prevent recurrent stroke and cardiovascular events. New England Journal of Medicine, 359(12), 1225-37. https://doi.org/10.1056/NEJMoa0804593

Yusuf, Salim ; Diener, Hans-Christoph ; Sacco, Ralph L ; Cotton, Daniel ; Ounpuu, Stephanie ; Lawton, William A ; Palesch, Yuko ; Martin, Reneé H ; Albers, Gregory W ; Bath, Philip ; Bornstein, Natan ; Chan, Bernard P L ; Chen, Sien-Tsong ; Cunha, Luis ; Dahlöf, Björn ; De Keyser, Jacques ; Donnan, Geoffrey A ; Estol, Conrado ; Gorelick, Philip ; Gu, Vivian ; Hermansson, Karin ; Hilbrich, Lutz ; Kaste, Markku ; Lu, Chuanzhen ; Machnig, Thomas ; Pais, Prem ; Roberts, Robin ; Skvortsova, Veronika ; Teal, Philip ; Toni, Danilo ; VanderMaelen, Cam ; Voigt, Thor ; Weber, Michael ; Yoon, Byung-Woo ; PRoFESS Study Group ; Passmore, Peter. / Telmisartan to prevent recurrent stroke and cardiovascular events. In: New England Journal of Medicine. 2008 ; Vol. 359, No. 12. pp. 1225-37.

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title = "Telmisartan to prevent recurrent stroke and cardiovascular events",

abstract = "Prolonged lowering of blood pressure after a stroke reduces the risk of recurrent stroke. In addition, inhibition of the renin-angiotensin system in high-risk patients reduces the rate of subsequent cardiovascular events, including stroke. However, the effect of lowering of blood pressure with a renin-angiotensin system inhibitor soon after a stroke has not been clearly established. We evaluated the effects of therapy with an angiotensin-receptor blocker, telmisartan, initiated early after a stroke.",

author = "Salim Yusuf and Hans-Christoph Diener and Sacco, {Ralph L} and Daniel Cotton and Stephanie Ounpuu and Lawton, {William A} and Yuko Palesch and Martin, {Rene{\'e} H} and Albers, {Gregory W} and Philip Bath and Natan Bornstein and Chan, {Bernard P L} and Sien-Tsong Chen and Luis Cunha and Bj{\"o}rn Dahl{\"o}f and {De Keyser}, Jacques and Donnan, {Geoffrey A} and Conrado Estol and Philip Gorelick and Vivian Gu and Karin Hermansson and Lutz Hilbrich and Markku Kaste and Chuanzhen Lu and Thomas Machnig and Prem Pais and Robin Roberts and Veronika Skvortsova and Philip Teal and Danilo Toni and Cam VanderMaelen and Thor Voigt and Michael Weber and Byung-Woo Yoon and {PRoFESS Study Group} and Peter Passmore",

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Yusuf, S, Diener, H-C, Sacco, RL, Cotton, D, Ounpuu, S, Lawton, WA, Palesch, Y, Martin, RH, Albers, GW, Bath, P, Bornstein, N, Chan, BPL, Chen, S-T, Cunha, L, Dahlöf, B, De Keyser, J, Donnan, GA, Estol, C, Gorelick, P, Gu, V, Hermansson, K, Hilbrich, L, Kaste, M, Lu, C, Machnig, T, Pais, P, Roberts, R, Skvortsova, V, Teal, P, Toni, D, VanderMaelen, C, Voigt, T, Weber, M, Yoon, B-W, PRoFESS Study Group & Passmore, P 2008, 'Telmisartan to prevent recurrent stroke and cardiovascular events', New England Journal of Medicine, vol. 359, no. 12, pp. 1225-37. https://doi.org/10.1056/NEJMoa0804593

Telmisartan to prevent recurrent stroke and cardiovascular events. / Yusuf, Salim; Diener, Hans-Christoph; Sacco, Ralph L; Cotton, Daniel; Ounpuu, Stephanie; Lawton, William A; Palesch, Yuko; Martin, Reneé H; Albers, Gregory W; Bath, Philip; Bornstein, Natan; Chan, Bernard P L; Chen, Sien-Tsong; Cunha, Luis; Dahlöf, Björn; De Keyser, Jacques; Donnan, Geoffrey A; Estol, Conrado; Gorelick, Philip; Gu, Vivian; Hermansson, Karin; Hilbrich, Lutz; Kaste, Markku; Lu, Chuanzhen; Machnig, Thomas; Pais, Prem; Roberts, Robin; Skvortsova, Veronika; Teal, Philip; Toni, Danilo; VanderMaelen, Cam; Voigt, Thor; Weber, Michael; Yoon, Byung-Woo; PRoFESS Study Group ; Passmore, Peter.

In: New England Journal of Medicine, Vol. 359, No. 12, 18.09.2008, p. 1225-37.

Research output: Contribution to journal › Article › peer-review

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T1 - Telmisartan to prevent recurrent stroke and cardiovascular events

AU - Yusuf, Salim

AU - Diener, Hans-Christoph

AU - Sacco, Ralph L

AU - Cotton, Daniel

AU - Ounpuu, Stephanie

AU - Lawton, William A

AU - Palesch, Yuko

AU - Martin, Reneé H

AU - Albers, Gregory W

AU - Bath, Philip

AU - Bornstein, Natan

AU - Chan, Bernard P L

AU - Chen, Sien-Tsong

AU - Cunha, Luis

AU - Dahlöf, Björn

AU - De Keyser, Jacques

AU - Donnan, Geoffrey A

AU - Estol, Conrado

AU - Gorelick, Philip

AU - Gu, Vivian

AU - Hermansson, Karin

AU - Hilbrich, Lutz

AU - Kaste, Markku

AU - Lu, Chuanzhen

AU - Machnig, Thomas

AU - Pais, Prem

AU - Roberts, Robin

AU - Skvortsova, Veronika

AU - Teal, Philip

AU - Toni, Danilo

AU - VanderMaelen, Cam

AU - Voigt, Thor

AU - Weber, Michael

AU - Yoon, Byung-Woo

AU - PRoFESS Study Group

AU - Passmore, Peter

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AB - Prolonged lowering of blood pressure after a stroke reduces the risk of recurrent stroke. In addition, inhibition of the renin-angiotensin system in high-risk patients reduces the rate of subsequent cardiovascular events, including stroke. However, the effect of lowering of blood pressure with a renin-angiotensin system inhibitor soon after a stroke has not been clearly established. We evaluated the effects of therapy with an angiotensin-receptor blocker, telmisartan, initiated early after a stroke.

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DO - 10.1056/NEJMoa0804593

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VL - 359

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