Telmisartan to prevent recurrent stroke and cardiovascular events

Salim Yusuf, Hans-Christoph Diener, Ralph L Sacco, Daniel Cotton, Stephanie Ounpuu, William A Lawton, Yuko Palesch, Reneé H Martin, Gregory W Albers, Philip Bath, Natan Bornstein, Bernard P L Chan, Sien-Tsong Chen, Luis Cunha, Björn Dahlöf, Jacques De Keyser, Geoffrey A Donnan, Conrado Estol, Philip Gorelick, Vivian GuKarin Hermansson, Lutz Hilbrich, Markku Kaste, Chuanzhen Lu, Thomas Machnig, Prem Pais, Robin Roberts, Veronika Skvortsova, Philip Teal, Danilo Toni, Cam VanderMaelen, Thor Voigt, Michael Weber, Byung-Woo Yoon, PRoFESS Study Group, Peter Passmore

Research output: Contribution to journalArticlepeer-review

587 Citations (Scopus)

Abstract

Prolonged lowering of blood pressure after a stroke reduces the risk of recurrent stroke. In addition, inhibition of the renin-angiotensin system in high-risk patients reduces the rate of subsequent cardiovascular events, including stroke. However, the effect of lowering of blood pressure with a renin-angiotensin system inhibitor soon after a stroke has not been clearly established. We evaluated the effects of therapy with an angiotensin-receptor blocker, telmisartan, initiated early after a stroke.
Original languageEnglish
Pages (from-to)1225-37
Number of pages13
JournalNew England Journal of Medicine
Volume359
Issue number12
DOIs
Publication statusPublished - 18 Sep 2008

ASJC Scopus subject areas

  • Medicine(all)

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