Temporal and geographical distribution of measles virus genotypes

B. K. Rima, J. A. P. Earle, R. P. Yeo, L. Herlihy, K. Baczko, V. Ter Meulen, J. Carabana, M. Caballero, M. L. Celma, R. Fernandez-Munoz

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

The nucleotide sequence encoding the C terminus of the nucleocapsid protein of measles virus (MV) is the most variable in the genome. The sequence of this region is reported for 21 new MV strains and for virus RNA obtained from cases of subacute panencephalitis (SSPE) tissue. The nucleotide sequence of a total of 65 MV strains has been analysed using the CLUSTAL program to determine the relationships between the strains. An unrooted tree shows that eight different genotypes can be discerned amongst the sequences analysed so far. The data show that the C-terminal coding sequence of the nucleocapsid gene, although highly variable between strains, is stable in a given strain and does not appear to diverge in tissue culture. It therefore provides a good 'signature' sequence for specific genotypes. The sequence of this region can be used to discriminate new imported viruses from old 'endemic' strains of MV in a geographical area. The different genotypes are not geographically restricted although some appear to be the mainly 'endemic' types in large areas of the world. In global terms there appears to be at least four co-circulating genotypes of MV. The low level of divergence in the Edmonston lineage group isolated before 1970 indicates that some isolates are probably laboratory contaminants. This applies to some SSPE isolates such as the Halle, Mantooth and Horta-Barbosa strains as well as some wild-type isolates from that period.
Original languageEnglish
Pages (from-to)1173-1180
Number of pages8
JournalJournal of General Virology
Volume76
Issue number5
DOIs
Publication statusPublished - 01 May 1995

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Measles virus
Genotype
Subacute Sclerosing Panencephalitis
Nucleocapsid
RNA Viruses
Genome
Viruses
Genes

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Rima, B. K., Earle, J. A. P., Yeo, R. P., Herlihy, L., Baczko, K., Ter Meulen, V., ... Fernandez-Munoz, R. (1995). Temporal and geographical distribution of measles virus genotypes. Journal of General Virology, 76(5), 1173-1180. https://doi.org/10.1099/0022-1317-76-5-1173
Rima, B. K. ; Earle, J. A. P. ; Yeo, R. P. ; Herlihy, L. ; Baczko, K. ; Ter Meulen, V. ; Carabana, J. ; Caballero, M. ; Celma, M. L. ; Fernandez-Munoz, R. / Temporal and geographical distribution of measles virus genotypes. In: Journal of General Virology. 1995 ; Vol. 76, No. 5. pp. 1173-1180.
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Rima, BK, Earle, JAP, Yeo, RP, Herlihy, L, Baczko, K, Ter Meulen, V, Carabana, J, Caballero, M, Celma, ML & Fernandez-Munoz, R 1995, 'Temporal and geographical distribution of measles virus genotypes', Journal of General Virology, vol. 76, no. 5, pp. 1173-1180. https://doi.org/10.1099/0022-1317-76-5-1173

Temporal and geographical distribution of measles virus genotypes. / Rima, B. K. ; Earle, J. A. P. ; Yeo, R. P.; Herlihy, L.; Baczko, K.; Ter Meulen, V.; Carabana, J.; Caballero, M.; Celma, M. L.; Fernandez-Munoz, R.

In: Journal of General Virology, Vol. 76, No. 5, 01.05.1995, p. 1173-1180.

Research output: Contribution to journalArticle

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T1 - Temporal and geographical distribution of measles virus genotypes

AU - Rima, B. K.

AU - Earle, J. A. P.

AU - Yeo, R. P.

AU - Herlihy, L.

AU - Baczko, K.

AU - Ter Meulen, V.

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