Temporal characteristics of cardiomyocyte hypertrophy in the spontaneously hypertensive rat.

David Bell, Elizabeth Kelso, C.C.H. Argent, G.R. Lee, A.R. Allen, Barbara McDermott

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40 Citations (Scopus)


Background The spontaneously hypertensive rat (SHR) is frequently used as model of cardiovascular disease, with considerable disparity in reported parameters of hypertrophy. The aim of this study was to assess the temporal changes occurring during the development and progression of cardiomyocyte hypertrophy in SHR, subsequent to pressure overload, compared to changes associated with normal aging using the normotensive Wistar–Kyoto (WKY) rat. Methods Ventricular cardiomyocytes were isolated from rats at 8, 12, 16, 20 and 24 weeks, and parameters of hypertrophy (cell dimensions, protein mass, de novo protein synthesis, and gene expression) and function (contraction and hypertrophic responsiveness in vitro) were assessed. Results Hypertension was evident at =7 weeks in SHRs. Heart:body mass ratio, cardiomyocyte protein mass and width were elevated (P
Original languageEnglish
Pages (from-to)71-78
Number of pages8
JournalCardiovascular Pathology
Volume13 (2)
Issue number2
Publication statusPublished - Mar 2004

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pathology and Forensic Medicine


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