Temporal characteristics of cardiomyocyte hypertrophy in the spontaneously hypertensive rat.

David Bell; Elizabeth Kelso; C.C.H. Argent; G.R. Lee; A.R. Allen; Barbara McDermott

doi:10.1016/S1054-8807(03)00135-2

Temporal characteristics of cardiomyocyte hypertrophy in the spontaneously hypertensive rat.

David Bell, Elizabeth Kelso, C.C.H. Argent, G.R. Lee, A.R. Allen, Barbara McDermott

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Background The spontaneously hypertensive rat (SHR) is frequently used as model of cardiovascular disease, with considerable disparity in reported parameters of hypertrophy. The aim of this study was to assess the temporal changes occurring during the development and progression of cardiomyocyte hypertrophy in SHR, subsequent to pressure overload, compared to changes associated with normal aging using the normotensive Wistar–Kyoto (WKY) rat. Methods Ventricular cardiomyocytes were isolated from rats at 8, 12, 16, 20 and 24 weeks, and parameters of hypertrophy (cell dimensions, protein mass, de novo protein synthesis, and gene expression) and function (contraction and hypertrophic responsiveness in vitro) were assessed. Results Hypertension was evident at =7 weeks in SHRs. Heart:body mass ratio, cardiomyocyte protein mass and width were elevated (P

Original language	English
Pages (from-to)	71-78
Number of pages	8
Journal	Cardiovascular Pathology
Volume	13 (2)
Issue number	2
DOIs	https://doi.org/10.1016/S1054-8807(03)00135-2
Publication status	Published - Mar 2004

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Pathology and Forensic Medicine

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10.1016/S1054-8807(03)00135-2

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T1 - Temporal characteristics of cardiomyocyte hypertrophy in the spontaneously hypertensive rat.

AU - Bell, David

AU - Kelso, Elizabeth

AU - Argent, C.C.H.

AU - Lee, G.R.

AU - Allen, A.R.

AU - McDermott, Barbara

PY - 2004/3

Y1 - 2004/3

N2 - Background The spontaneously hypertensive rat (SHR) is frequently used as model of cardiovascular disease, with considerable disparity in reported parameters of hypertrophy. The aim of this study was to assess the temporal changes occurring during the development and progression of cardiomyocyte hypertrophy in SHR, subsequent to pressure overload, compared to changes associated with normal aging using the normotensive Wistar–Kyoto (WKY) rat. Methods Ventricular cardiomyocytes were isolated from rats at 8, 12, 16, 20 and 24 weeks, and parameters of hypertrophy (cell dimensions, protein mass, de novo protein synthesis, and gene expression) and function (contraction and hypertrophic responsiveness in vitro) were assessed. Results Hypertension was evident at =7 weeks in SHRs. Heart:body mass ratio, cardiomyocyte protein mass and width were elevated (P

AB - Background The spontaneously hypertensive rat (SHR) is frequently used as model of cardiovascular disease, with considerable disparity in reported parameters of hypertrophy. The aim of this study was to assess the temporal changes occurring during the development and progression of cardiomyocyte hypertrophy in SHR, subsequent to pressure overload, compared to changes associated with normal aging using the normotensive Wistar–Kyoto (WKY) rat. Methods Ventricular cardiomyocytes were isolated from rats at 8, 12, 16, 20 and 24 weeks, and parameters of hypertrophy (cell dimensions, protein mass, de novo protein synthesis, and gene expression) and function (contraction and hypertrophic responsiveness in vitro) were assessed. Results Hypertension was evident at =7 weeks in SHRs. Heart:body mass ratio, cardiomyocyte protein mass and width were elevated (P

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Temporal characteristics of cardiomyocyte hypertrophy in the spontaneously hypertensive rat.

Abstract

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