Ten years of protein kinase B signalling: a hard Akt to follow

Derek Brazil, B.A. Hemmings

Research output: Contribution to journalArticlepeer-review

993 Citations (Scopus)


It is ten years since the publication of three papers describing the cloning of a new proto-oncogene serine/threonine kinase termed protein kinase B (PKB)/Akt. Key roles for this protein kinase in cellular processes such as glucose metabolism, cell proliferation, apoptosis, transcription and cell migration are now well established. The explosion of publications involving PKB/Akt in the past three years emphasizes the high level of current interest in this signalling molecule. This review focuses on tracing the characterization of this kinase, through the elucidation of its mechanism of regulation, to its role in regulating physiological and pathophysiological processes,to our current understanding of the biology of PKB/Akt, and prospects for the future.
Original languageEnglish
Pages (from-to)657-664
Number of pages8
JournalTrends in Biochemical Sciences
Issue number11
Publication statusPublished - 01 Nov 2001

ASJC Scopus subject areas

  • Biochemistry

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