Abstract
I discovered that 2,5OAS family of proteins was transcriptionally upregulated by BRCA1 and interferon gamma in a synergistic manner. This correlated with synergistically induced apoptosis and both the induction of 2,5OAS and the accompanying apoptosis could be inhibited by 2,5OAS specific siRNA proving 2,5OAS was the apoptotic effector.
Original language | English |
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Pages (from-to) | 5492-5501 |
Number of pages | 10 |
Journal | Oncogene |
Volume | 24(35) |
Issue number | 35 |
DOIs | |
Publication status | Published - 18 Aug 2005 |
ASJC Scopus subject areas
- Cancer Research
- Genetics
- Molecular Biology