The 2,5 Oligoadenylate Synthetase/RNaseL pathway is a novel effector of BRCA1 - and interferon-gamma-mediated apoptosis

Paul Mullan, R. Kennedy, Niamh Buckley, J. O'Brien, Alison Hosey, Patrick Johnston, Paul Harkin

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

I discovered that 2,5OAS family of proteins was transcriptionally upregulated by BRCA1 and interferon gamma in a synergistic manner. This correlated with synergistically induced apoptosis and both the induction of 2,5OAS and the accompanying apoptosis could be inhibited by 2,5OAS specific siRNA proving 2,5OAS was the apoptotic effector.
Original languageEnglish
Pages (from-to)5492-5501
Number of pages10
JournalOncogene
Volume24(35)
Issue number35
DOIs
Publication statusPublished - 18 Aug 2005

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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