The 2,5 Oligoadenylate Synthetase/RNaseL pathway is a novel effector of BRCA1 - and interferon-gamma-mediated apoptosis

Paul Mullan; R. Kennedy; Niamh Buckley; J. O'Brien; Alison Hosey; Patrick Johnston; Paul Harkin

doi:10.1038/sj.onc.1208698

The 2,5 Oligoadenylate Synthetase/RNaseL pathway is a novel effector of BRCA1 - and interferon-gamma-mediated apoptosis

Paul Mullan, R. Kennedy, Niamh Buckley, J. O'Brien, Alison Hosey, Patrick Johnston, Paul Harkin

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

I discovered that 2,5OAS family of proteins was transcriptionally upregulated by BRCA1 and interferon gamma in a synergistic manner. This correlated with synergistically induced apoptosis and both the induction of 2,5OAS and the accompanying apoptosis could be inhibited by 2,5OAS specific siRNA proving 2,5OAS was the apoptotic effector.

Original language	English
Pages (from-to)	5492-5501
Number of pages	10
Journal	Oncogene
Volume	24(35)
Issue number	35
DOIs	https://doi.org/10.1038/sj.onc.1208698
Publication status	Published - 18 Aug 2005

ASJC Scopus subject areas

Cancer Research
Genetics
Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.onc.1208698

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title = "The 2,5 Oligoadenylate Synthetase/RNaseL pathway is a novel effector of BRCA1 - and interferon-gamma-mediated apoptosis",

abstract = "I discovered that 2,5OAS family of proteins was transcriptionally upregulated by BRCA1 and interferon gamma in a synergistic manner. This correlated with synergistically induced apoptosis and both the induction of 2,5OAS and the accompanying apoptosis could be inhibited by 2,5OAS specific siRNA proving 2,5OAS was the apoptotic effector.",

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AU - Mullan, Paul

AU - Kennedy, R.

AU - Buckley, Niamh

AU - O'Brien, J.

AU - Hosey, Alison

AU - Johnston, Patrick

AU - Harkin, Paul

PY - 2005/8/18

Y1 - 2005/8/18

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AB - I discovered that 2,5OAS family of proteins was transcriptionally upregulated by BRCA1 and interferon gamma in a synergistic manner. This correlated with synergistically induced apoptosis and both the induction of 2,5OAS and the accompanying apoptosis could be inhibited by 2,5OAS specific siRNA proving 2,5OAS was the apoptotic effector.

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SN - 0950-9232

VL - 24(35)

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JO - Oncogene

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IS - 35

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The 2,5 Oligoadenylate Synthetase/RNaseL pathway is a novel effector of BRCA1 - and interferon-gamma-mediated apoptosis

Abstract

ASJC Scopus subject areas

UN SDGs

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